Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Haifa, 349888, Israel.
Faculty of Natural Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Haifa, 349888, Israel; Departments of Genetics and Medicine, Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, New York, 10461, USA.
Ageing Res Rev. 2020 Sep;62:101093. doi: 10.1016/j.arr.2020.101093. Epub 2020 Jun 2.
The process of aging can be defined as the sum accumulation of damages and changes in metabolism during the life of an organism, due to both genetic predisposition and stochastic damage. During the gestational period and following parturition, similar damage can be seen due to the strenuous effect on the maternal body, exhibited on both the physiological and cellular level. In this review, we will focus on the similar physiological and cellular characteristics exhibited during pregnancy and aging, including induction of and response to oxidative stress, inflammation, and degradation of telomeres. We will evaluate any similar processes between aging and pregnancy by comparing common biomarkers, pathologies, and genetic and epigenetic effects, to establish the pregnant body as a model for aging. This review will approach the connection both in respect to current theories on aging as a byproduct of natural selection, and regarding unrelated biochemical similarities between the two, drawing on existing studies and models in humans and other species where relevant alike. Furthermore, we will show the response of the pregnant body to these changes, and through that illuminate unique areas of potential study to advance our knowledge of the maladies relating to aging and pregnancy, and an avenue for solutions.
衰老过程可以定义为生物体在其一生中由于遗传倾向和随机损伤而导致代谢过程中损伤和变化的总和积累。在妊娠期间和分娩后，由于对母体身体的巨大影响，在生理和细胞水平上都可以看到类似的损伤。在这篇综述中，我们将重点关注妊娠和衰老过程中表现出的相似的生理和细胞特征，包括氧化应激、炎症和端粒降解的诱导和反应。我们将通过比较常见的生物标志物、病理学以及遗传和表观遗传效应，来评估衰老和妊娠之间的相似过程，将怀孕的身体作为衰老的模型。这篇综述将从衰老作为自然选择的副产品的现有理论，以及两者之间不相关的生化相似性这两个方面来探讨这种联系，同时参考人类和其他相关物种中的现有研究和模型。此外，我们将展示怀孕身体对这些变化的反应，从而阐明潜在的研究领域，以推进我们对与衰老和怀孕相关的疾病的认识，并为解决这些问题提供途径。
