Arun Gayatri, Aggarwal Disha, Spector David L
Envisagenics, 101 Avenue of the Americas, New York, NY 10013, USA.
Graduate Program in Genetics, Stony Brook University, Stony Brook, New York, NY 11794, USA.
Noncoding RNA. 2020 Jun 3;6(2):22. doi: 10.3390/ncrna6020022.
The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. () is one of the most well-studied lncRNAs. is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, has been shown to be dispensable for normal development and viability in mice. Interestingly, accumulating evidence suggests that plays an important role in numerous diseases including cancer. Here, we discuss the current state-of-knowledge in regard to with respect to its function, role in diseases, and the potential therapeutic opportunities for targeting using antisense oligonucleotides and small molecules.
哺乳动物基因组普遍转录，许多长链非编码RNA（lncRNA）转录本的功能意义正逐渐被阐明。（）是研究最深入的lncRNAs之一。是一种高度保守的核保留lncRNA，在细胞和组织中大量表达，并已显示出以依赖于上下文的方式在转录和转录后水平上调节基因。然而，已证明对小鼠的正常发育和生存力是可有可无的。有趣的是，越来越多的证据表明在包括癌症在内的多种疾病中起重要作用。在这里，我们讨论了关于其功能、在疾病中的作用以及使用反义寡核苷酸和小分子靶向的潜在治疗机会方面的当前知识状态。
