Long Non-Coding RNA: Functional Implications.

The mammalian genome is pervasively transcribed and the functional significance of many long non-coding RNA (lncRNA) transcripts are gradually being elucidated. () is one of the most well-studied lncRNAs. is a highly conserved nuclear retained lncRNA that is abundantly expressed in cells and tissues and has been shown to play a role in regulating genes at both the transcriptional and post-transcriptional levels in a context-dependent manner. However, has been shown to be dispensable for normal development and viability in mice. Interestingly, accumulating evidence suggests that plays an important role in numerous diseases including cancer. Here, we discuss the current state-of-knowledge in regard to with respect to its function, role in diseases, and the potential therapeutic opportunities for targeting using antisense oligonucleotides and small molecules.