莳萝（莳萝）粉补充对 2 型糖尿病患者临床和代谢状况的影响。
The effects of Anethum graveolens (dill) powder supplementation on clinical and metabolic status in patients with type 2 diabetes.
机构信息
Department of Nutrition, Nutrition and Metabolic Diseases Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
出版信息
Trials. 2020 Jun 5;21(1):483. doi: 10.1186/s13063-020-04401-3.
BACKGROUND
The objective of this study was to investigate the effects of Anethum graveolens (dill) powder supplementation on glycemic control, lipid profile, some antioxidants and inflammatory markers, and gastrointestinal symptoms in patients with type 2 diabetes.
MATERIALS AND METHODS
In this study, 42 patients with type 2 diabetes were randomly allocated to intervention and control groups and received either 3 g/day dill powder or placebo (3 capsules/day, 1 g each). Fasting blood sugar, insulin, homeostatic model assessment of insulin resistance, lipid profile, high-sensitivity C-reactive protein, total antioxidant capacity, malondialdehyde and gastrointestinal symptoms were measured in all of the subjects at baseline and postintervention.
RESULTS
The dill powder supplementation significantly decreased the mean serum levels of insulin, homeostatic model assessment of insulin resistance, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde in the intervention group in comparison with the baseline measurements (P < 0.05). Furthermore, the mean serum levels of high-density lipoprotein and total antioxidant capacity were significantly increased in the intervention group in comparison with the baseline measurement (P < 0.05). Colonic motility disorder was the only gastrointestinal symptom whose frequency was significantly reduced by supplementation (P = 0.01). The mean changes in insulin, low-density lipoprotein cholesterol, total cholesterol and malondialdehyde were significantly lower in the intervention group than in the control group (P < 0.05). In addition, the mean changes in high-density lipoprotein were significantly higher in the intervention group than in the control group (P < 0.05).
CONCLUSION
Dill powder supplementation can be effective in controlling the glycemic, lipid, stress oxidative and gastrointestinal symptoms in patients with type 2 diabetes.
TRIAL REGISTRATION
Iran Clinical Trials Registry: IRCT20120704010181N12. Registered on 12 May 2018.
背景
本研究旨在探讨莳萝粉（莳萝）补充对 2 型糖尿病患者血糖控制、血脂谱、一些抗氧化剂和炎症标志物以及胃肠道症状的影响。
材料与方法
在这项研究中，将 42 例 2 型糖尿病患者随机分为干预组和对照组，分别给予 3g/d 莳萝粉或安慰剂（每天 3 粒，每粒 1g）。所有受试者在基线和干预后均测量空腹血糖、胰岛素、稳态模型评估的胰岛素抵抗、血脂谱、高敏 C 反应蛋白、总抗氧化能力、丙二醛和胃肠道症状。
结果
与基线测量相比，莳萝粉补充组的血清胰岛素、稳态模型评估的胰岛素抵抗、低密度脂蛋白胆固醇、总胆固醇和丙二醛水平均显著降低（P<0.05）。此外，与基线测量相比，莳萝粉补充组的高密度脂蛋白和总抗氧化能力血清水平显著升高（P<0.05）。补充后结肠蠕动障碍是唯一胃肠道症状的频率显著降低（P=0.01）。与对照组相比，干预组的胰岛素、低密度脂蛋白胆固醇、总胆固醇和丙二醛的平均变化明显较低（P<0.05）。此外，干预组的高密度脂蛋白的平均变化明显高于对照组（P<0.05）。
结论
莳萝粉补充可以有效地控制 2 型糖尿病患者的血糖、血脂、应激氧化和胃肠道症状。
试验注册
伊朗临床试验注册处：IRCT20120704010181N12。注册于 2018 年 5 月 12 日。
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