大鼠经口、腹腔内、气管内或肺内给予芘后芘及羟基芘的尿粪排泄情况。
Urinary and faecal excretion of pyrene and hydroxypyrene by rats after oral, intraperitoneal, intratracheal or intrapulmonary application.
作者信息
Jacob J, Brune H, Gettbarn G, Grimmer D, Heinrich U, Mohtashamipur E, Norpoth K, Pott F, Wenzel-Hartung R
机构信息
Biochemical Institute for Environmental Carcinogens, Grosshansdorf, F.R.G.
出版信息
Cancer Lett. 1989 Jul 1;46(1):15-20. doi: 10.1016/0304-3835(89)90209-7.
The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53.4%), intraperitoneal (3.1%), intratracheal (30-37%) and intrapulmonary application (0.003%) to rats has been determined by means of gas chromatography/mass spectrometry and the excretion rates were found to depend on the mode of application. With regard to the low urinary excretion rates, 1-hydroxypyrene seems not to be very suitable as a biological marker for PAH exposure to man.
通过气相色谱/质谱法测定了给大鼠经口（53.4%）、腹腔内（3.1%）、气管内（30 - 37%）和肺内（0.003%）给予芘和1 - 羟基芘后的尿粪排泄情况，发现排泄率取决于给药方式。鉴于尿排泄率较低，1 - 羟基芘似乎不太适合作为人类多环芳烃暴露的生物标志物。
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