Jacob J, Brune H, Gettbarn G, Grimmer D, Heinrich U, Mohtashamipur E, Norpoth K, Pott F, Wenzel-Hartung R
Biochemical Institute for Environmental Carcinogens, Grosshansdorf, F.R.G.
Cancer Lett. 1989 Jul 1;46(1):15-20. doi: 10.1016/0304-3835(89)90209-7.
The urinary and faecal excretion of pyrene and 1-hydroxypyrene after oral (53.4%), intraperitoneal (3.1%), intratracheal (30-37%) and intrapulmonary application (0.003%) to rats has been determined by means of gas chromatography/mass spectrometry and the excretion rates were found to depend on the mode of application. With regard to the low urinary excretion rates, 1-hydroxypyrene seems not to be very suitable as a biological marker for PAH exposure to man.
通过气相色谱/质谱法测定了给大鼠经口（53.4%）、腹腔内（3.1%）、气管内（30 - 37%）和肺内（0.003%）给予芘和1 - 羟基芘后的尿粪排泄情况，发现排泄率取决于给药方式。鉴于尿排泄率较低，1 - 羟基芘似乎不太适合作为人类多环芳烃暴露的生物标志物。
