Ramezani Fatemeh, Razmgir Maryam, Tanha Kiarash, Nasirinezhad Farinaz, Neshastehriz Ali, Bahrami-Ahmadi Amir, Hamblin Michael R, Janzadeh Atousa
Physiology Research Center, Faculty of Medicine. Iran University of Medical Sciences, Tehran, Iran.
Medical Librarianship and Information Science, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran.
Physiol Behav. 2020 Oct 1;224:112977. doi: 10.1016/j.physbeh.2020.112977. Epub 2020 Jun 3.
In recent years, photobiomodulation therapy (PBMT) has found many applications in various medical fields. Studies of PBMT on spinal cord injury (SCI) have mostly used laser sources in experimental animal models. The purpose of this study was to summarize studies that have employed PBMT for various kinds of SCI in animals. A thorough search in databases including MEDLINE, EMBASE, SCOPUS, and Web of Science, with the removal of unrelated articles, yielded 16 relevant articles. The meta-analysis showed that PBMT was effective in improving post-SCI movement in the first 14 days (MD = 1.593 (95% CI: 1.110 to 2.075; p <0.001, I = 51.9%) and this improvement became even greater thereafter (MD = 2.086 (95% CI: 1.570 to 2.603; p = <0.001. I= 90.3%). Time of irradiation (<300 sec or >300 sec), gender (male or female), injury model (contusion or compression, radiation protocol (<14 days or ≥14days), laser wavelength (<800nm or >800nm) and injury severity (moderate or severe) were found to be factors that can affect PBM efficacy for SCI treatment. PBMT has an anti-inflammatory effect, is effective in reducing the size of spinal cord lesions and helps to absorb administrated proteins and stem cells to the lesion site.
近年来，光生物调节疗法（PBMT）在各个医学领域有诸多应用。关于PBMT对脊髓损伤（SCI）的研究大多在实验动物模型中使用激光源。本研究的目的是总结在动物中采用PBMT治疗各种类型SCI的研究。在包括MEDLINE、EMBASE、SCOPUS和科学网在内的数据库中进行全面检索，并剔除无关文章，得到16篇相关文章。荟萃分析表明，PBMT在SCI后的前14天对改善运动有效（MD = 1.593（95%CI：1.110至2.075；p <0.001，I = 51.9%），此后这种改善更加明显（MD = 2.086（95%CI：1.570至2.603；p = <0.001，I = 90.3%）。发现照射时间（<300秒或>300秒）、性别（男或女）、损伤模型（挫伤或压迫）、照射方案（<14天或≥14天）、激光波长（<800nm或>800nm）和损伤严重程度（中度或重度）是影响PBMT治疗SCI疗效的因素。PBMT具有抗炎作用，能有效减小脊髓损伤的大小，并有助于将施用的蛋白质和干细胞吸收到损伤部位。
