Department of Persian Medicine, School of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Orthopedic Surgeries, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Complement Ther Med. 2020 Jun;51:102429. doi: 10.1016/j.ctim.2020.102429. Epub 2020 May 14.
The aim of present study was to review and categorize the clinical trials investigating the clinical effects of different botanical parts of dates compared with any controls.
All clinical trials (randomized, pilot, quasi-experimental, cross-over. and non-randomized clinical trials) evaluating the clinical effects of date palm from 2000 until August 2019 in English and Persian languages were included in this systematic review. The methodological quality of the included studies was evaluated according to the risk of bias assessment of Cochrane handbook of systematic reviews, and then reported using Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) statement.
Twenty-six studies met the inclusion criteria. Studies were performed in 8 categories based on different botanical parts of date palm. These categories were obstetrics, gynecology, oncology, dermatology, hematology, gastroenterology, endocrinology, metabolism, and infertility. A total of 38 % of included studies were randomized controlled trials. Further, 80 % of the included studies had performance and detection bias. Finally, about 50 % of them had selection bias and about 20 % had attrition and reporting bias.
The widespread consumption of date palm as medicinal and botanical plant suggests the importance of this plant in human healthcare. The clinical trials conducted so far have explained a number of clinical effects of date palm. However, there is not enough clinical evidence to support the clinical effects in other review articles and traditional medical systems, and further randomized controlled trials with robust designs and methods are required.
本研究旨在回顾和分类比较不同枣科植物部位与任何对照相比的临床效果的临床试验。
本系统评价纳入了 2000 年至 2019 年 8 月间以英文和波斯文发表的所有评估枣椰树临床效果的临床试验（随机、先导、准实验、交叉和非随机临床试验）。根据 Cochrane 系统评价手册的偏倚风险评估标准评估纳入研究的方法学质量，然后使用系统评价和荟萃分析报告的首选报告项目（PRISMA）陈述进行报告。
26 项研究符合纳入标准。这些研究基于枣椰树的不同植物部位分为 8 个类别。这些类别包括产科、妇科、肿瘤学、皮肤科、血液学、胃肠病学、内分泌学、代谢和不育。纳入研究中共有 38%为随机对照试验。此外，80%的纳入研究存在实施和检测偏倚。最后，约 50%的研究存在选择偏倚，约 20%的研究存在失访和报告偏倚。
枣椰树作为药用和植物被广泛食用，表明其在人类保健中的重要性。迄今为止进行的临床试验已经解释了枣椰树的一些临床效果。然而，没有足够的临床证据支持其他综述文章和传统医学系统中的临床效果，需要进一步进行设计和方法稳健的随机对照试验。
