a Molecular Microbiology and Genomics Consultants , Zotzenheim , Germany.
Crit Rev Microbiol. 2018 Sep;44(5):619-632. doi: 10.1080/1040841X.2018.1481013. Epub 2018 Jun 17.
To the multiple factors that may eventually result in colorectal cancer (CRC), strains of E. coli have now been added, in particular strains producing colibactin from their polyketide synthesis (pks) locus. The evidence and mechanistic explanations for this unfortunate effect of what is in most cases a harmless commensal are discussed in the first part of this review. In the second part, observations are presented and discussed that do not fit with the hypothesis that colibactin-producing E. coli produce CRC. The last part of this review is reserved for an alternative explanation of the function of this enigmatic colibactin, a toxin that has not yet been isolated. It is hypothesized that E. coli preferentially colonizes cancerous lesions as an effect rather than a cause and that colibactin production provides a selective advantage to compete with other bacteria.
除了多种可能最终导致结直肠癌（CRC）的因素外，现在又增加了大肠杆菌菌株，特别是那些从多酮合成（pks）基因座产生肠菌素的菌株。在本综述的第一部分讨论了这种在大多数情况下无害共生菌的不幸影响的证据和机制解释。在第二部分，提出并讨论了一些与产肠菌素大肠杆菌产生 CRC 的假设不符的观察结果。本综述的最后一部分保留给这个神秘的肠菌素的功能的另一种解释，这是一种尚未被分离出来的毒素。假设大肠杆菌优先定植于癌性病变是一种结果而不是原因，并且肠菌素的产生为与其他细菌竞争提供了选择性优势。
