Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Florida Department of Health, Tallahassee, Florida, USA.
Clin Infect Dis. 2021 Aug 2;73(3):506-512. doi: 10.1093/cid/ciaa727.
Neonatal herpes simplex virus infection (nHSV) leads to severe morbidity and mortality, but national incidence is uncertain. Florida regulations require that healthcare providers report cases, and clinical laboratories report test results when herpes simplex virus (HSV) is detected. We estimated nHSV incidence using laboratory-confirmed provider-reported cases and electronic laboratory reports (ELR) stored separately from provider-reported cases. Mortality was estimated using provider-reported cases, ELR, and vital statistics death records.
For 2011-2017, we reviewed: provider-reported cases (infants ≤ 60 days of age with HSV infection confirmed by culture or polymerase chain reaction [PCR]), ELR of HSV-positive culture or PCR results in the same age group, and death certificates containing International Classification of Disease, Tenth Revision, codes for herpes infection: P35.2, B00.0-B00.9, and A60.0-A60.9. Provider-reported cases were matched against ELR reports. Death certificates were matched with provider and ELR reports. Chapman's capture-recapture method was used to estimate nHSV incidence and mortality. Mortality from all 3 sources was estimated using log-linear modeling.
Providers reported 114 nHSV cases, and ELR identified 197 nHSV cases. Forty-six cases were common to both datasets, leaving 265 unique nHSV reports. Chapman's estimate suggests 483 (95% confidence interval [CI], 383-634) nHSV cases occurred (31.5 infections per 100 000 live births). The nHSV deaths were reported by providers (n = 9), ELR (n = 18), and vital statistics (n = 31), totaling 34 unique reports. Log-linear modeling estimates 35.8 fatal cases occurred (95% CI, 34-40).
Chapman's estimates using data collected over 7 years in Florida conclude nHSV infections occurred at a rate of 1 per 3000 live births.
新生儿单纯疱疹病毒感染（nHSV）可导致严重的发病率和死亡率，但全国发病率尚不确定。佛罗里达州的法规要求医疗保健提供者报告病例，临床实验室在检测到单纯疱疹病毒（HSV）时报告检测结果。我们使用实验室确诊的报告病例和与报告病例分开存储的电子实验室报告（ELR）来估计 nHSV 的发病率。死亡率使用报告病例、ELR 和生命统计死亡记录来估计。
对于 2011 年至 2017 年，我们审查了以下内容：报告病例（60 天龄以下的婴儿，HSV 感染通过培养或聚合酶链反应[PCR]证实）、相同年龄组的 HSV 阳性培养或 PCR 结果的 ELR，以及包含国际疾病分类第十版代码的死亡证明疱疹感染：P35.2、B00.0-B00.9 和 A60.0-A60.9。报告病例与 ELR 报告相匹配。死亡证明与报告病例和 ELR 报告相匹配。使用 Chapman 的捕获-再捕获法估计 nHSV 的发病率和死亡率。使用对数线性模型估计所有 3 个来源的死亡率。
提供者报告了 114 例 nHSV 病例，ELR 确定了 197 例 nHSV 病例。两个数据集共有 46 例病例，剩下 265 例为独特的 nHSV 报告。Chapman 的估计表明，佛罗里达州发生了 483 例（95%置信区间[CI]，383-634）nHSV 病例（每 100000 例活产中有 31.5 例感染）。nHSV 死亡由提供者（n=9）、ELR（n=18）和生命统计（n=31）报告，总计 34 例。对数线性模型估计有 35.8 例死亡病例（95%CI，34-40）。
使用佛罗里达州 7 年来收集的数据进行 Chapman 估计，得出 nHSV 感染的发生率为每 3000 例活产 1 例。
