Department of Ophthalmology, University of Yamanashi, Shimokato 1110, Chuo, Yamanashi, 409-3898, Japan.
School of Medicine, New York University, New York, NY, US.
Int Ophthalmol. 2020 Oct;40(10):2735-2742. doi: 10.1007/s10792-020-01460-y. Epub 2020 Jun 7.
To investigate whether plasma high sensitivity C-reactive protein (hs-CRP) level is associated with exudative age-related macular degeneration (AMD) as well as variants of ARMS2 A69S and CFH I62V in patients with exudative AMD.
A case-control study was done comparing CRP among patients with exudative AMD including those with polypoidal choroidal vasculopathy, typical AMD and retinal angiomatous proliferation, and CRP were also compared between cases and controls. Plasma CRP was measured from peripheral blood using latex nepherometry for all participants. Genotyping of ARMS2 A69S and CFH I62V was performed for all patients with exudative AMD using TaqMan technology.
Among 125 patients with exudative AMD, including 31 with typical neovascular AMD, 73 with PCV and 21 with RAP lesions and 150 controls, CRP levels were higher in exudative AMD than in controls. (P = 2.7 × 10) There was not a significant difference in hs-CRP levels among AMD subtypes. Neither variants of ARMS2 nor CFH was associated with hs-CRP level in patients with exudative AMD. A multiple regression analysis revealed that gender male, presence of exudative AMD and presence of cardiovascular diseases were associated with increased plasma hs-CRP.
Plasma hs-CRP was elevated independent of variants of ARMS2 A69S and CFH I62V in patients with exudative AMD.
研究血浆高敏 C 反应蛋白（hs-CRP）水平是否与渗出性年龄相关性黄斑变性（AMD）以及 ARMS2 A69S 和 CFH I62V 变异体相关，这些变异体存在于渗出性 AMD 患者中。
进行了病例对照研究，比较了包括息肉样脉络膜血管病变、典型 AMD 和视网膜血管性增殖在内的渗出性 AMD 患者的 CRP 水平，并比较了病例和对照组之间的 CRP 水平。所有参与者均采用乳胶比浊法测量外周血中的 CRP。使用 TaqMan 技术对所有渗出性 AMD 患者进行 ARMS2 A69S 和 CFH I62V 基因分型。
在 125 例渗出性 AMD 患者中，包括 31 例典型新生血管性 AMD、73 例 PCV 和 21 例 RAP 病变患者和 150 例对照者中，渗出性 AMD 患者的 CRP 水平高于对照组（P=2.7×10）。AMD 各亚型之间 hs-CRP 水平无显著差异。ARMS2 或 CFH 的变异体与渗出性 AMD 患者的 hs-CRP 水平均无相关性。多元回归分析显示，男性、渗出性 AMD 的存在以及心血管疾病的存在与血浆 hs-CRP 升高有关。
在渗出性 AMD 患者中，血浆 hs-CRP 升高独立于 ARMS2 A69S 和 CFH I62V 变异体。
