癌症干细胞：关于鉴定及治疗意义的全面综述
Cancer stem cells: A comprehensive review on identification and therapeutic implications.
作者信息
Varun B R, Jayanthi P, Ramani Pratibha
机构信息
Department of Oral and Maxillofacial Pathology, PMS College of Dental Sciences and Research, Thiruvananthapuram, Tamil Nadu, India.
Department of Oral and Maxillofacial Pathology, Azeezia College of Dental Sciences and Research, Kollam, Kerala, India.
出版信息
J Oral Maxillofac Pathol. 2020 Jan-Apr;24(1):190. doi: 10.4103/jomfp.JOMFP_336_19. Epub 2020 May 8.
Abstract
Cancer stem cells (CSCs) are distinct subpopulations of tumor cells that possess the ability for perpetual self-renewal and proliferation. They produce downstream progenitor cells and cancer cells that drive tumor growth. Studies of many cancer types including oral squamous cell carcinoma (OSCC) have identified CSCs using specific markers, but it is still unclear as to where in the stem cell hierarchy these markers fall. This is compounded further by the presence of multiple CSC subtypes within OSCC, making investigation reliant on the use of multiple markers. This review paper focuses on the current knowledge in CSC markers including OCT4, SOX2, NANOG, aldehyde dehydrogenase 1, CD44, CD24, CD133 and Musashi-1, highlighting their use and validity in OSCC CSC research.
摘要
癌症干细胞（CSCs）是肿瘤细胞中的独特亚群，具有永久自我更新和增殖的能力。它们产生驱动肿瘤生长的下游祖细胞和癌细胞。包括口腔鳞状细胞癌（OSCC）在内的许多癌症类型的研究已经使用特定标志物鉴定出了癌症干细胞，但这些标志物在干细胞层级结构中的位置仍不清楚。OSCC中存在多种癌症干细胞亚型，这使得研究依赖于多种标志物的使用，情况变得更加复杂。这篇综述文章聚焦于癌症干细胞标志物的现有知识，包括OCT4、SOX2、NANOG、醛脱氢酶1、CD44、CD24、CD133和Musashi-1，强调了它们在OSCC癌症干细胞研究中的用途和有效性。
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本文引用的文献
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Front Oncol. 2017 Jun 2;7:112. doi: 10.3389/fonc.2017.00112. eCollection 2017.
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Characterization of Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma.中度分化口腔黏膜鳞状细胞癌中癌症干细胞的特征分析
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