1979 - 1982年欧共体国家中伴有潜在可避免的严重染色体异常的出生频率。
Frequency of births with potentially avoidable serious chromosomal anomalies in EEC countries, 1979-1982.
作者信息
Ten Kate L P, Dolk H, Cornel M C, De Wals P, Te Meerman G J, Lechat M F, Weatherall J A
机构信息
Department of Human Genetics, University of Groningen, Netherlands.
出版信息
J Epidemiol Community Health. 1988 Sep;42(3):266-70. doi: 10.1136/jech.42.3.266.
Child bearing at an early age and prenatal cytogenetic diagnosis in pregnant women of advanced age, combined with selective abortion, make it possible to avoid the birth of many children with serious chromosomal anomalies. To see how many of such births were still avoidable in Europe, data from 16 regional EUROCAT registers of congenital anomalies in nine EEC countries were analysed. In the period 1979-1982 about 30% of children with unbalanced anomalies of autosomes were born (live- and still-births) to mothers over 35 years of age. This amounts to an estimated 1300 cases yearly in the entire population of the nine countries. The approach shows the possible use of registry data for monitoring effects of avoidance strategies.
早育以及高龄孕妇的产前细胞遗传学诊断，再结合选择性流产，使得避免许多患有严重染色体异常的儿童出生成为可能。为了解在欧洲仍有多少此类出生是可以避免的，分析了来自九个欧洲经济共同体国家的16个地区性欧洲先天性异常监测（EUROCAT）登记处的数据。在1979 - 1982年期间，35岁以上的母亲所生（活产和死产）的患有常染色体不平衡异常的儿童约占30%。在这九个国家的总人口中，估计每年有1300例这种情况。该方法表明登记处数据可用于监测避免策略的效果。
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