Avomeen, Ann Arbor, MI, USA.
Okra Medical, Inc., Johns Island, SC, USA.
Sci Rep. 2021 Jan 13;11(1):1129. doi: 10.1038/s41598-020-80388-w.
Substance use disorders are a significant public health issue. Options to dispose of controlled medications are limited, increasing the risk of diversion. Providing an alternative for disposal, a chemical denaturant, SafeMedWaste, was designed to destroy controlled substances irreversibly and safely be placed in non-hazardous landfills. Via HPLC-MS, four formulations of SafeMedWaste were tested with 34 different liquid controlled medications from DEA schedules I-V. Beta testing assessed the efficacy of SafeMedWaste in a clinical setting and on waste generated in a manufacturing setting. Furthermore, a formulation of SafeMedWaste was tested on solid controlled medications. All 34 of the liquid medications tested (e.g., amphetamine, diazepam, fentanyl, ketamine) were fully destroyed in SafeMedWaste within 2-24 h. Analysis of a beta test sample of SafeMedWaste containing fentanyl, midazolam, and morphine waste collected in a hospital showed full denaturation of these drugs in 24 h. Variants of SafeMedWaste were optimized to denature six different controlled substance waste samples from a manufacturing facility. In contrast to side-by-side studies with a charcoal disposal system using the same drugs, SafeMedWaste fully inactivated and destroyed the controlled substances in the waste streams. Another formulation of SafeMedWaste was tested on solid medications, which were fully denatured in 48-72 h. In conclusion, SafeMedWaste irreversibly denatures controlled medications that present a problem in our society.
物质使用障碍是一个重大的公共卫生问题。处理受控药物的选择有限，增加了转移的风险。为了提供一种替代处理方法，设计了一种化学变性剂 SafeMedWaste，旨在不可逆地破坏受控物质，并安全地放置在无害的垃圾填埋场中。通过 HPLC-MS，测试了 SafeMedWaste 的四种配方，其中包括来自 DEA 附表 I-V 的 34 种不同的液体受控药物。β测试评估了 SafeMedWaste 在临床环境中和在制造环境中产生的废物中的效果。此外，还对 SafeMedWaste 的一种配方进行了固体受控药物的测试。测试的 34 种液体药物（如安非他命、地西泮、芬太尼、氯胺酮）在 SafeMedWaste 中 2-24 小时内完全被破坏。对含有芬太尼、咪达唑仑和吗啡废物的 SafeMedWaste 的β测试样本进行分析，表明这些药物在 24 小时内完全变性。对 SafeMedWaste 的变体进行了优化，以处理来自制造设施的六种不同受控物质废物样本。与使用相同药物的炭处理系统的并排研究相比，SafeMedWaste 完全使废物流中的受控物质失活和破坏。SafeMedWaste 的另一种配方用于固体药物的测试，这些药物在 48-72 小时内完全变性。总之，SafeMedWaste 不可逆地破坏了我们社会中存在问题的受控药物。
