International Genomics Research Center (IGRC), Jiangsu University, Zhenjiang, 212013, P. R. China.
Department of Immunology, School of Medicine, Jiangsu University, Zhenjiang, 212013, P. R. China.
J Microbiol. 2020 Jul;58(7):531-542. doi: 10.1007/s12275-020-0026-3. Epub 2020 Jun 10.
Among the major bacterial secretions, outer membrane vesicles (OMVs) are significant and highly functional. The proteins and other biomolecules identified within OMVs provide new insights into the possible functions of OMVs in bacteria. OMVs are rich in proteins, nucleic acids, toxins and virulence factors that play a critical role in bacteria-host interactions. In this review, we discuss some proteins with multifunctional features from bacterial OMVs and their role involving the mechanisms of bacterial survival and defence. Proteins with moonlighting activities in OMVs are discussed based on their functions in bacteria. OMVs harbour many other proteins that are important, such as proteins involved in virulence, defence, and competition. Overall, OMVs are a power-packed aid for bacteria, harbouring many defensive and moonlighting proteins and acting as a survival kit in case of an emergency or as a defence weapon. In summary, OMVs can be defined as bug-out bags for bacterial defence and, therefore, survival.
在主要的细菌分泌物中，外膜囊泡（OMVs）是重要且功能强大的。在 OMVs 中鉴定的蛋白质和其他生物分子为 OMVs 在细菌中的可能功能提供了新的见解。OMVs 富含蛋白质、核酸、毒素和毒力因子，这些在细菌-宿主相互作用中起着至关重要的作用。在这篇综述中，我们讨论了一些具有多功能特征的细菌 OMVs 中的蛋白质及其涉及细菌生存和防御机制的作用。根据其在细菌中的功能讨论了具有多重功能的蛋白质。OMVs 还含有许多其他重要的蛋白质，如参与毒力、防御和竞争的蛋白质。总的来说，OMVs 是细菌的有力辅助工具，包含许多防御和兼职蛋白质，在紧急情况下或作为防御武器充当生存工具包。总之，OMVs 可以被定义为细菌防御和生存的应急包。
