Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, School of Environmental Science and Engineering, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, China.
State Key Laboratory of Environmental and Biological Analysis, Department of Chemistry, Hong Kong Baptist University, Hong Kong, China.
Ecotoxicol Environ Saf. 2020 Sep 15;201:110827. doi: 10.1016/j.ecoenv.2020.110827. Epub 2020 Jun 11.
Numerous experimental and epidemiological studies have demonstrated that exposure to PM may result in pathogenesis of several major cardiovascular diseases (CVDs), which can be attributed to the combined adverse effects induced by the complicated components of PM. Organic materials, which are major components of PM, contain thousands of chemicals, and most of them are environmental hazards. However, the contamination profile and contribution to overall toxicity of PM-bound organic components (OCs) have not been thoroughly evaluated yet. Herein, we aim to provide an overview of the literature on PM-bound hydrophobic OCs, with an emphasis on the chemical identity and reported impairments on the cardiovascular system, including the potential exposure routes and mechanisms. We first provide an update on the worldwide mass concentration and composition data of PM, and then, review the contamination profile of PM-bound hydrophobic OCs, including constitution, concentration, distribution, formation, source, and identification. In particular, the link between exposure to PM-bound hydrophobic OCs and CVDs and its possible underlying mechanisms are discussed to evaluate the possible risks of PM-bound hydrophobic OCs on the cardiovascular system and to provide suggestions for future studies.
大量的实验和流行病学研究表明，暴露于 PM 可能导致几种主要心血管疾病（CVDs）的发病机制，这可以归因于 PM 复杂成分引起的联合不良影响。有机物质是 PM 的主要成分之一，其中包含数千种化学物质，其中大多数对环境有害。然而，PM 结合有机成分（OCs）的污染状况及其对整体毒性的贡献尚未得到彻底评估。本文旨在提供有关 PM 结合疏水性 OCs 的文献综述，重点介绍化学特性及其对心血管系统的报道损伤，包括潜在的暴露途径和机制。我们首先提供了关于 PM 全球质量浓度和成分数据的最新信息，然后综述了 PM 结合疏水性 OCs 的污染状况，包括组成、浓度、分布、形成、来源和鉴定。特别讨论了暴露于 PM 结合疏水性 OCs 与 CVDs 之间的联系及其可能的潜在机制，以评估 PM 结合疏水性 OCs 对心血管系统的可能风险，并为未来的研究提供建议。
