Tukwasibwe Stephen, Nakimuli Annettee, Traherne James, Chazara Olympe, Jayaraman Jyothi, Trowsdale John, Moffett Ashley, Jagannathan Prasanna, Rosenthal Philip J, Cose Stephen, Colucci Francesco
Makerere University, Kampala, Uganda.
University of Cambridge, Cambridge, UK.
Cell Mol Immunol. 2020 Aug;17(8):799-806. doi: 10.1038/s41423-020-0482-z. Epub 2020 Jun 15.
Malaria is one of the deadliest infectious diseases in the world. Immune responses to Plasmodium falciparum malaria vary among individuals and between populations. Human genetic variation in immune system genes is likely to play a role in this heterogeneity. Natural killer (NK) cells produce inflammatory cytokines in response to malaria infection, kill intraerythrocytic Plasmodium falciparum parasites by cytolysis, and participate in the initiation and development of adaptive immune responses to plasmodial infection. These functions are modulated by interactions between killer-cell immunoglobulin-like receptors (KIRs) and human leukocyte antigens (HLAs). Therefore, variations in KIR and HLA genes can have a direct impact on NK cell functions. Understanding the role of KIRs and HLAs in immunity to malaria can help to better characterize antimalarial immune responses. In this review, we summarize the different KIRs and HLAs associated with immunity to malaria thus far.
疟疾是世界上最致命的传染病之一。对恶性疟原虫疟疾的免疫反应在个体之间和人群之间存在差异。免疫系统基因的人类遗传变异可能在这种异质性中起作用。自然杀伤（NK）细胞在疟疾感染时产生炎性细胞因子，通过细胞溶解作用杀死红细胞内的恶性疟原虫寄生虫，并参与对疟原虫感染的适应性免疫反应的启动和发展。这些功能受杀伤细胞免疫球蛋白样受体（KIR）与人类白细胞抗原（HLA）之间相互作用的调节。因此，KIR和HLA基因的变异可直接影响NK细胞功能。了解KIR和HLA在疟疾免疫中的作用有助于更好地描述抗疟免疫反应。在这篇综述中，我们总结了迄今为止与疟疾免疫相关的不同KIR和HLA。
