School of Pharmacy, Bengbu Medical College, 2600 Donghai Road, Bengbu 233030, Anhui, People's Republic of China.
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, People's Republic of China.
J Nat Prod. 2020 Jun 26;83(6):2045-2053. doi: 10.1021/acs.jnatprod.9b01283. Epub 2020 Jun 16.
Epipolythiodioxopiperazines (ETPs) are a class of biologically active fungal secondary metabolites characterized by a bridged polysulfide piperazine ring. Regularly, the sulfide functionality is attached in the α-positions of the dioxopiperazine scaffold. However, ETPs possessing irregular sulfur bridges have rarely been explored. This review summarizes that 83 compounds of this subtype have been isolated and characterized since the discovery of gliovirin in 1982. Herein, particular emphasis is given to the isolation, chemistry, and biological activity of this subtype. For a better understanding, a relevant summary focusing on the source microorganisms and their taxonomy is provided and will help elucidate the fascinating chemistry and biology of these unusual ETPs.
表氧杂二氮戊环（ETP）是一类具有生物活性的真菌次级代谢产物，其特征为桥连多硫化物哌嗪环。通常，亚砜官能团连接在二氧杂哌嗪骨架的α-位。然而，具有不规则硫桥的 ETP 很少被探索。本文综述了自 1982 年发现Gliovirin 以来，已分离鉴定出 83 种此类亚型的化合物。本文特别强调了该亚型的分离、化学和生物活性。为了更好地理解，提供了一个关于来源微生物及其分类学的相关摘要，这将有助于阐明这些不寻常的 ETP 的迷人化学和生物学。
