Zheng Chang-Ji, Kim Young-Ho, Kim Won-Gon
Functional Metabolite Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Republic of Korea.
Biosci Biotechnol Biochem. 2007 Aug;71(8):1979-83. doi: 10.1271/bbb.70167. Epub 2007 Aug 7.
In the course of our screening for new antibacterials from microbial metabolites, two new dioxopiperazine metabolites, glioperazines B (1) and C (2), together with the known compound, glioperazine (3), were isolated from the mycelia of a liquid fermentation culture of the fungus, Bionectra byssicola F120. The structures of compounds 1 and 2 were assigned on the basis of MS and NMR data. Compound 1 is an unusual dioxopiperazine metabolite containing an OMe group at the alpha-carbon of the amino acid residue. Compound 1 showed weak antibacterial activity against various strains of S. aureus, including methicillin-resistant S. aureus (MRSA) and quinolone-resistant S. aureus (QRSA), while 2 and 3 did not show such activity.
在我们从微生物代谢产物中筛选新型抗菌剂的过程中，从真菌Bionectra byssicola F120液体发酵培养物的菌丝体中分离出两种新的二氧代哌嗪代谢产物，即glioperazines B（1）和C（2），以及已知化合物glioperazine（3）。化合物1和2的结构是根据质谱和核磁共振数据确定的。化合物1是一种不寻常的二氧代哌嗪代谢产物，在氨基酸残基的α-碳上含有一个甲氧基。化合物1对包括耐甲氧西林金黄色葡萄球菌（MRSA）和耐喹诺酮金黄色葡萄球菌（QRSA）在内的各种金黄色葡萄球菌菌株表现出微弱的抗菌活性，而化合物2和3则没有这种活性。
