Department of Nuclear Medicine, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Haidian Street, Beijing, 100853, China.
Department of Radiology, Chinese People's Liberation Army Strategic Support Force Characteristic Medical Center, Beijing, 100101, China.
Cancer Imaging. 2020 Jun 16;20(1):39. doi: 10.1186/s40644-020-00317-y.
Evaluate the feasibility of fluorine-18 (F) fluorodeoxyglucose (FDG) positron emission tomography (PET) and magnetic resonance (MR) imaging in patients with gastric cancer by optimizing the scan protocol and to compare the image quality to F FDG PET and computed tomography (CT).
The PET/CT and PET/MR imaging were sequentially performed in 30 patients with gastric cancer diagnosed by gastroscope using a single-injection-with-dual-imaging protocol. After intravenous injection of F-FDG (mean, 249 MBq), PET/CT imaging including low-dose CT was performed (mean uptake time, 47 ± 6 min), and PET/MR imaging including a T1-weighted Dixon sequence for attenuation correction and two different T2-weighted sequences was subsequently acquired (88 ± 15 min after F-FDG injection). Four series of images (CT from PET/CT, T1W, T2W Half-Fourier acquisition single-shot turbo spin-echo [T2W-HASTE] and T2W-BLADE from PET/MR) were visually evaluated using a 3-4 points scale for: (1) image artifacts, (2) lesion conspicuity and (3) image fusion quality. The characteristics of the primary lesions were assessed and compared between the PET/CT and PET/MR acquisitions.
The image quality and lesion conspicuity of the T2W-HASTE images were significantly improved compared to that of the T2W-BLADE images. A significantly higher number of artifacts were seen in the T2W-HASTE images compared with the T1W and CT images (p < 0. 05). No differences in the accuracy of image fusion between PET/MR and PET/CT (p > 0. 05); however, significant difference was seen in the lesion conspicuity measurements (p < 0.05) with T2W-HASTE being superior. For information about the primary lesion characteristics, the T2W-HASTE images provided the most successful identifications compared with those of the T1W and PET/CT (13vs7vs5) images.
PET/MR with the T2W-HASTE was better at revealing the details of local stomach lesions compared with PET/CT imaging. Combining the PET/MR with the T2W-HASTE technique is a promising imaging method for diagnosing and staging gastric cancer.
通过优化扫描方案，评估氟-18（F）氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）和磁共振（MR）成像在胃癌患者中的可行性，并将图像质量与 F-FDG PET 和计算机断层扫描（CT）进行比较。
30 例经胃镜诊断为胃癌的患者采用单次注射双影像方案进行 PET/CT 和 PET/MR 成像。静脉注射 F-FDG（平均 249MBq）后，行包括低剂量 CT 的 PET/CT 成像（平均摄取时间 47±6min），随后行包括 T1 加权 Dixon 序列衰减校正和两种不同 T2 加权序列的 PET/MR 成像（注射 F-FDG 后 88±15min）。使用 3-4 分制视觉评估 4 组图像（来自 PET/CT 的 CT、T1W、T2W 半傅里叶采集单次激发快速自旋回波 [T2W-HASTE] 和 T2W-BLADE 来自 PET/MR）：（1）图像伪影，（2）病变显影度，（3）图像融合质量。评估并比较了原发肿瘤的特征在 PET/CT 和 PET/MR 采集之间。
与 T2W-BLADE 图像相比，T2W-HASTE 图像的质量和病变显影度有显著提高。与 T1W 和 CT 图像相比，T2W-HASTE 图像中明显有更多的伪影（p<0.05）。PET/MR 与 PET/CT 之间的图像融合准确性无差异（p>0.05）；然而，在病变显影度测量方面存在显著差异（p<0.05），T2W-HASTE 更好。对于原发肿瘤特征的信息，与 T1W 和 PET/CT（13vs7vs5）图像相比，T2W-HASTE 图像提供了最成功的识别。
与 PET/CT 成像相比，PET/MR 联合 T2W-HASTE 技术更能显示胃局部病变的细节。结合 PET/MR 和 T2W-HASTE 技术是一种有前途的诊断和分期胃癌的成像方法。
