Amirinejad Ali, Heshmati Javad, Shidfar Farzad
Student Research Committee, Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Songhor Healthcare Center, Kermanshah University of Medical Science, Kermanshah, Iran.
J Diabetes Metab Disord. 2019 Dec 13;19(1):565-573. doi: 10.1007/s40200-019-00443-w. eCollection 2020 Jun.
Previous studies have shown thylakoids, the membrane proteins which are extracted from green leaves like spinach, can induce satiety through homeostatic and non-homeostatic pathways. In this study, we reviewed the current human literature on thylakoids' characteristics and their relationship to satiety regulation and weight loss.
A systematic search of literature published between January 1990 and May 2019 was conducted on the electronic databases; including WEB OF SCIENCE, Cochrane Library, MEDLINE, Scopus, and EMBASE databases. We included all clinical trials that addressed the effects of thylakoids or chloroplast intake on satiety and weight loss.
After excluding non-human studies, non-RCTs, duplications, studies with irrelevant data and interventions, eight studies were included in the qualitative synthesis. All studies supported this hypothesis that thylakoids reduce the feeling of hunger by increasing postprandial cholecystokinin and leptin and decreasing serum ghrelin, but the consequences of thylakoid intake on anthropometric characteristics were controversial.
In conclusion, our results may approve this postulation that receiving a thylakoid-enriched meal can decrease appetite and probably food intake in short term; however, more studies are needed to explore the effects of long term supplementation with thylakoids on weight loss in human subjects.
先前的研究表明，类囊体这种从菠菜等绿叶中提取的膜蛋白，可通过稳态和非稳态途径诱导饱腹感。在本研究中，我们回顾了当前关于类囊体特性及其与饱腹感调节和体重减轻关系的人体文献。
对1990年1月至2019年5月期间发表的文献在电子数据库中进行系统检索，包括科学网、考克兰图书馆、医学期刊数据库、Scopus和EMBASE数据库。我们纳入了所有探讨类囊体或叶绿体摄入对饱腹感和体重减轻影响的临床试验。
在排除非人体研究、非随机对照试验、重复研究、数据和干预不相关的研究后，八项研究被纳入定性综合分析。所有研究均支持这一假设，即类囊体通过增加餐后胆囊收缩素和瘦素水平以及降低血清胃饥饿素水平来减轻饥饿感，但类囊体摄入对人体测量学特征的影响存在争议。
总之，我们的结果可能支持这一假设，即摄入富含类囊体的餐食可在短期内降低食欲并可能减少食物摄入量；然而，需要更多研究来探讨长期补充类囊体对人体体重减轻的影响。
