运动训练对2型糖尿病患者脑源性神经营养因子（BDNF）的影响：随机对照试验的系统评价
The Effects of Exercise Training on the Brain-Derived Neurotrophic Factor (BDNF) in the Patients with Type 2 Diabetes: A Systematic Review of the Randomized Controlled Trials.
作者信息
Jamali Afsaneh, Shahrbanian Shahnaz, Morteza Tayebi Seyed
机构信息
Department of Sport Science, Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
Department of Exercise Physiology, Faculty of Sport Science, Allameh Tabataba'i University, Tehran, Iran.
出版信息
J Diabetes Metab Disord. 2020 May 6;19(1):633-643. doi: 10.1007/s40200-020-00529-w. eCollection 2020 Jun.
PURPOSE
Glucose dysregulation is one of the distinctive features of type 2 diabetes that is associated with an increased risk of cognitive impairment and dementia. The low concentrations of brain-derived neurotrophic factor (BDNF) are reported in people with insulin resistance, metabolic syndrome, and type 2 diabetes. BDNF can be increased by an adjustment in lifestyle including caloric restriction and exercise training. Studies have reported controversial findings about physical activity and its association with BDNF, but there is no comprehensive conclusions on this issue. The aim of this study was to systematically review the effects of exercise training on BDNF levels in patients with type 2 diabetes.
METHODS
The electronic databases of Embase, Pedro, PubMed, Medline, Cochrane Library, as well as the Google Scholar search engine were used to obtain the related data about the role of exercise training on BDNF levels in patients with type 2 diabetes. The search period was set from inception to August 2019. Keywords of "exercise", "training", "physical activity", "brain-derived neurotrophic factor", "type 2 diabetes", and "randomized clinical trials", were used in persian and English. The PEDro scale was used to evaluate the quality of the included articles. Finally, 11 articles (four human and seven animal articles) with medium to high quality were included in the study which 5 articles reported elevation (one human and four animal articles), 4 articles reported a reduction (one human and three animal articles), and 2 articles reported no changes (both of them in human articles) in BDNF level following the exercise training.
CONCLUSION
Decreased energy intake and increased energy expenditure through exercise training may modulate BDNF levels in patients with type 2 diabetes.
目的
血糖失调是2型糖尿病的显著特征之一，与认知障碍和痴呆风险增加有关。胰岛素抵抗、代谢综合征和2型糖尿病患者的脑源性神经营养因子（BDNF）浓度较低。通过调整生活方式，包括热量限制和运动训练，可以提高BDNF水平。关于体育活动及其与BDNF的关联，研究报告了相互矛盾的结果，但在这个问题上尚无全面结论。本研究的目的是系统评价运动训练对2型糖尿病患者BDNF水平的影响。
方法
使用Embase、Pedro、PubMed、Medline、Cochrane图书馆等电子数据库以及谷歌学术搜索引擎，获取关于运动训练对2型糖尿病患者BDNF水平作用的相关数据。检索期设定为从数据库建立到2019年8月。使用波斯语和英语的关键词“运动”“训练”“体育活动”“脑源性神经营养因子”“2型糖尿病”和“随机临床试验”。使用PEDro量表评估纳入文章的质量。最后，11篇中高质量文章（4篇人体研究和7篇动物研究文章）被纳入研究，其中5篇文章报告运动训练后BDNF水平升高（1篇人体研究和4篇动物研究文章），4篇文章报告降低（1篇人体研究和3篇动物研究文章），2篇文章报告无变化（均为人体研究文章）。
结论
通过运动训练减少能量摄入和增加能量消耗可能调节2型糖尿病患者的BDNF水平。
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