Nosratzehi Tahereh
Dental Research Center and Dept. of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran.
J Dent (Shiraz). 2017 Dec;18(4):237-243.
Squamous cell carcinoma of oral cavity is of malignant tumors, which causes cancerous complications. DNA damage, mainly because of products of oxidative stress like reactive oxygen species, is a frequent mutagenic that triggers carcinoma. Smoking increases the probability of cancer incidence. Saliva is the first biological medium to interact with external compounds, especially smoking substances. The present study overviews the salivary level of some remarkable compounds in relation with smoking and squamous cell carcinoma. To collect data, English literature was searched in databases including PubMed, ScienceDirect and Google Scholar. The keywords used for search were as follows: 'Carcinoma, Squamous Cell', 'Smoking', 'Saliva', and 'Biomarkers'. The inclusion criteria were the presence of salivary chemical factors in relation with oral cancer and influence by smoking. Out of 239 found articles, only 56 were selected. Our results demonstrated the potential role of salivary biochemistry to predict and/or treat complications with cancer in both smoker and non-smoker individuals. Changes in concentrations of salivary chemicals including antioxidants, total antioxidant, glutathione and uric acid, epithelial growth factor, cytokine biomarkers, superoxide dismutase activity, and transcriptome were related to squamous cell carcinoma and could be used as potential biomarkers for cancer prognosis; moreover, enhancement of antioxidant level might be a potential treatment.
口腔鳞状细胞癌是一种恶性肿瘤，会引发癌症并发症。DNA损伤主要是由活性氧等氧化应激产物引起的，是引发癌症的常见诱变因素。吸烟会增加患癌几率。唾液是与外部化合物，尤其是吸烟物质相互作用的第一种生物介质。本研究概述了与吸烟和鳞状细胞癌相关的一些显著化合物的唾液水平。为收集数据，在包括PubMed、ScienceDirect和谷歌学术在内的数据库中检索了英文文献。用于检索的关键词如下：“癌，鳞状细胞”、“吸烟”、“唾液”和“生物标志物”。纳入标准是存在与口腔癌相关且受吸烟影响的唾液化学因素。在找到的239篇文章中，仅选取了56篇。我们的结果表明，唾液生物化学在预测和/或治疗吸烟者和非吸烟者的癌症并发症方面具有潜在作用。唾液化学物质浓度的变化，包括抗氧化剂、总抗氧化剂、谷胱甘肽和尿酸、上皮生长因子、细胞因子生物标志物、超氧化物歧化酶活性和转录组，与鳞状细胞癌相关，可作为癌症预后的潜在生物标志物；此外，提高抗氧化剂水平可能是一种潜在的治疗方法。
