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Alteration of serum beta 2-microglobulin in oral carcinoma.口腔癌患者血清β2-微球蛋白的变化
Indian J Clin Biochem. 2002 Jul;17(2):104-7. doi: 10.1007/BF02867981.
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Demographic and clinical profile of oral squamous cell carcinoma patients: a retrospective study.口腔鳞状细胞癌患者的人口统计学和临床特征：一项回顾性研究。
Indian J Cancer. 2012 Jan-Mar;49(1):21-6. doi: 10.4103/0019-509X.98910.
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Trends in the epidemiology of oral squamous cell carcinoma in Western UP: an institutional study.印度北方邦西部口腔鳞状细胞癌的流行病学趋势：一项机构研究
Indian J Dent Res. 2010 Jul-Sep;21(3):316-9. doi: 10.4103/0970-9290.70782.
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Oral cancer and precancer: improving outcomes.口腔癌与癌前病变：改善治疗效果
Compend Contin Educ Dent. 2009 Oct;30(8):486-8, 490-4, 496-8 passim; quiz 504, 520.
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Overexpression of beta2-microglobulin is associated with poor survival in patients with oral cavity squamous cell carcinoma and contributes to oral cancer cell migration and invasion.β2-微球蛋白的过表达与口腔鳞状细胞癌患者的不良生存相关，并促进口腔癌细胞的迁移和侵袭。
Br J Cancer. 2008 Nov 4;99(9):1453-61. doi: 10.1038/sj.bjc.6604698. Epub 2008 Oct 7.
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Prevalence of oral lesions in relation to habits: Cross-sectional study in South India.与习惯相关的口腔病变患病率：印度南部的横断面研究。
Indian J Dent Res. 2006 Jul-Sep;17(3):121-5. doi: 10.4103/0970-9290.29877.
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Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations.口腔鳞状细胞癌：基因组改变的病因、发病机制及预后价值
Indian J Cancer. 2006 Apr-Jun;43(2):60-6. doi: 10.4103/0019-509x.25886.
8
Age specific incidence rate and pathological spectrum of oral cancer in Allahabad.阿拉哈巴德口腔癌的年龄别发病率及病理谱
Indian J Med Sci. 2003 Sep;57(9):400-4.
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Oral cancer and precancerous lesions.口腔癌及癌前病变
CA Cancer J Clin. 2002 Jul-Aug;52(4):195-215. doi: 10.3322/canjclin.52.4.195.
10
Lymphocyte DNA damage in cigarette factory workers measured by the Comet assay.采用彗星试验检测卷烟厂工人淋巴细胞DNA损伤情况。
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致癌物暴露个体血清β2-微球蛋白水平的评估：印度人群的临床研究

Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population.

作者信息

Saddiwal Rashmi, Hebbale Manjula, Sane Vikrant Dilip, Hiremutt Darshan, Gupta Rohan, Merchant Yash

机构信息

Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra India.

Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.

出版信息

J Maxillofac Oral Surg. 2017 Mar;16(1):53-57. doi: 10.1007/s12663-016-0914-6. Epub 2016 May 13.

DOI:10.1007/s12663-016-0914-6
PMID:28286385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5328866/
Abstract

AIM

The aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).

MATERIALS AND METHODS

The study included 60 patients 15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of β2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Statistical analysis of the data was done using Tuckey's test, ANOVA and independent sample test.

RESULTS

Results showed that β2-m was increased in individuals exposed to carcinogens without precancerous and cancerous lesion.

CONCLUSION

Serum β2-m can be used as a better indicator and can give an early indication of malignant change and therefore malignancy can be detected at an early and treatable stage.

摘要

目的

本研究旨在评估β2-微球蛋白（β2-m）作为口腔鳞状细胞癌（SCC）诊断及预后的生化参数的预后价值。

材料与方法

本研究纳入60例患者（15例口腔SCC、15例白斑、15例接触各种致癌物且无口腔癌或癌前病变的个体、15例健康个体）。使用免疫比浊法在Immulite全自动仪器上检测β2-m水平。采用Tuckey检验、方差分析和独立样本检验对数据进行统计学分析。

结果

结果显示，接触致癌物但无癌前和癌性病变的个体中β2-m升高。

结论

血清β2-m可作为一个更好的指标，能早期提示恶性变化，从而在可治疗的早期阶段检测到恶性肿瘤。