致癌物暴露个体血清β2-微球蛋白水平的评估：印度人群的临床研究
Estimation of Serum Beta 2-Microglobulin Levels in Individuals Exposed to Carcinogens: Clinical Study in Indian Population.
作者信息
Saddiwal Rashmi, Hebbale Manjula, Sane Vikrant Dilip, Hiremutt Darshan, Gupta Rohan, Merchant Yash
机构信息
Department of Oral Medicine and Radiology, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra India.
Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth Deemed University Dental College and Hospital, Pune, Maharashtra 411043 India.
出版信息
J Maxillofac Oral Surg. 2017 Mar;16(1):53-57. doi: 10.1007/s12663-016-0914-6. Epub 2016 May 13.
AIM
The aim of the study is to evaluate the prognostic value of β2-m as a biochemical parameter for the diagnosis and prognosis of oral squamous cell carcinoma (SCC).
MATERIALS AND METHODS
The study included 60 patients 15 oral SCC, 15 leukoplakia, 15 individuals exposed to various carcinogens and without oral cancerous or precancerous lesions, 15 healthy individuals). The levels of β2-m were estimated using chemi-luminescent immunometric assay on Immulite fully automated machine. Statistical analysis of the data was done using Tuckey's test, ANOVA and independent sample test.
RESULTS
Results showed that β2-m was increased in individuals exposed to carcinogens without precancerous and cancerous lesion.
CONCLUSION
Serum β2-m can be used as a better indicator and can give an early indication of malignant change and therefore malignancy can be detected at an early and treatable stage.
目的
本研究旨在评估β2-微球蛋白（β2-m）作为口腔鳞状细胞癌（SCC）诊断及预后的生化参数的预后价值。
材料与方法
本研究纳入60例患者（15例口腔SCC、15例白斑、15例接触各种致癌物且无口腔癌或癌前病变的个体、15例健康个体）。使用免疫比浊法在Immulite全自动仪器上检测β2-m水平。采用Tuckey检验、方差分析和独立样本检验对数据进行统计学分析。
结果
结果显示，接触致癌物但无癌前和癌性病变的个体中β2-m升高。
结论
血清β2-m可作为一个更好的指标，能早期提示恶性变化，从而在可治疗的早期阶段检测到恶性肿瘤。
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