Mahmood Rasool, Center of Excellence in Genomic Medicine Research (CEGMR),King Abdulaziz University, Jeddah, Saudi Arabia.
Saima Rubab Khan, Institute of molecular biology and biotechnology,The University of Lahore, Lahore, Pakistan.
Pak J Med Sci. 2014 May;30(3):466-71. doi: 10.12669/pjms.303.4985.
Objective : Oral squamous cell carcinoma (OSCC) is considered to be a serious life threatening issue for almost two decades. The objective of this study was to evaluate the over production of lipid peroxidation (LPO) byproducts and disturbances in antioxidant defense system in the pathogenesis of oral cancer. Methods : Lipid peroxidation and antioxidant status in OSCC patients were estimated and compared the sensitivity and specificity of circulating biomarkers (MDA, Sialic acid, Catalase, SOD, GSH and Neuraminidase) with β-2 microglobulin (β-2MG) at different thresholds in blood and saliva using receiver operating characteristics (ROC) curve design. R esults : Our results showed that the levels of MDA and Sialic acid were significantly increased in plasma of OSCC patients as compared to healthy subjects whereas antioxidant level was significantly decreased. Conclusion : ROC analysis indicated that MDA in saliva is a better diagnostic tool as compared to MDA in blood and β-2MG in blood is better diagnostic marker as compared to β-2MG level in saliva.
口腔鳞状细胞癌（OSCC）被认为是近二十年来严重威胁生命的问题。本研究旨在评估脂质过氧化（LPO）副产物的过度产生和抗氧化防御系统在口腔癌发病机制中的紊乱。
评估 OSCC 患者的脂质过氧化和抗氧化状态，并使用接收器操作特征（ROC）曲线设计比较循环生物标志物（MDA、唾液酸、过氧化氢酶、SOD、GSH 和神经氨酸酶）与β-2 微球蛋白（β-2MG）在血液和唾液中的不同阈值的敏感性和特异性。
我们的结果表明，与健康受试者相比，OSCC 患者血浆中的 MDA 和唾液酸水平显著升高，而抗氧化水平显著降低。
ROC 分析表明，唾液中的 MDA 比血液中的 MDA 更适合作为诊断工具，而血液中的β-2MG 比唾液中的β-2MG 更适合作为诊断标志物。
