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因冠状病毒病(COVID-19)引起的嗅觉和味觉障碍:当前证据综述。

Olfactory and gustatory dysfunctions due to the coronavirus disease (COVID-19): a review of current evidence.

机构信息

Department of Health Information Technology, Khalkhal University of Medical Sciences, Khalkhal, Iran.

Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Eur Arch Otorhinolaryngol. 2021 Feb;278(2):307-312. doi: 10.1007/s00405-020-06120-6. Epub 2020 Jun 17.

Abstract

INTRODUCTION

It is reported that coronavirus disease (COVID-19) can affect the sense of smell and taste of infected people. The pathobiology of this virus is still incompletely known, and it is therefore important to explore the impact of COVID-19 infections on olfactory and gustatory functions. We aimed to review current evidence on olfactory and gustatory dysfunctions caused by COVID-19.

METHODS

This study was a narrative review performed in 2020 to investigate the olfactory and gustatory dysfunctions of the COVID-19. We searched eight keywords in six databases to determine the related documents on the main objective of the study. To discover studies meeting the inclusion criteria, the authors screened the titles and abstracts of the identified articles. The appropriate studies were included and their results were discussed to make the final selection.

RESULTS

We have studied 24 current articles on the olfactory and gustatory dysfunctions due to COVID-19. A review of current studies has shown that we have a surge in the spread of olfactory and gustatory dysfunctions that happened during the epidemic of COVID-19 infection. Most studies (95.8%) have confirmed the symptoms of anosmia in patients with SARS-CoV-2 infection. A review of current studies showed that, in addition to anosmia, evidence of ageusia and dysgeusia (parageusia) was also seen in patients with COVID-19.

CONCLUSION

The results of our study support recent reports that SARS-CoV-2 may infect oral and nasal tissues and cause olfactory and gustatory dysfunctions. These findings may aid future research on the diagnosis, prevention, and treatment of COVID-19 consequences.

摘要

简介

据报道,冠状病毒病(COVID-19)可影响感染患者的嗅觉和味觉。该病毒的发病机制尚不完全清楚,因此探索 COVID-19 感染对嗅觉和味觉功能的影响很重要。我们旨在综述 COVID-19 引起的嗅觉和味觉障碍的现有证据。

方法

本研究为 2020 年进行的叙述性综述,旨在调查 COVID-19 的嗅觉和味觉障碍。我们在六个数据库中使用八个关键字来确定与主要研究目标相关的文献。为了发现符合纳入标准的研究,作者筛选了已确定文章的标题和摘要。纳入适当的研究并讨论其结果,以做出最终选择。

结果

我们研究了 24 篇关于 COVID-19 引起的嗅觉和味觉障碍的当前文章。对当前研究的综述表明,我们在 COVID-19 感染流行期间嗅觉和味觉障碍的传播急剧增加。大多数研究(95.8%)都证实了 SARS-CoV-2 感染患者存在嗅觉丧失的症状。对当前研究的综述表明,除了嗅觉丧失外,COVID-19 患者还出现味觉丧失和味觉障碍(味觉异常)的证据。

结论

我们的研究结果支持最近的报告,即 SARS-CoV-2 可能感染口腔和鼻腔组织并导致嗅觉和味觉障碍。这些发现可能有助于未来对 COVID-19 后果的诊断、预防和治疗的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87a0/7297932/604cab5be4b9/405_2020_6120_Fig1_HTML.jpg

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