College of Veterinary Medicine, Northwest A&F University, Shaanxi, China(1); State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau, China(1); School of Life Science and Technology, Weifang Medical University, Shandong, China(1).
College of Chemistry & Pharmacy, Northwest A&F University, Shaanxi, China(1).
Bioorg Chem. 2020 Aug;101:103922. doi: 10.1016/j.bioorg.2020.103922. Epub 2020 May 20.
The discovery of novel antibacterial molecules plays a key role in solving the current antibiotic crisis issue. Natural products have long been an important source of drug discovery. Herein, we reviewed 256 natural products from 11 structural classes in the period of 2016-01/2020, which were selected by SciFinder with new compounds or new structures and MICs lower than 10 μg/mL or 10 μM as criterions. This review will provide some effective antibacterial lead compounds for medicinal chemists, which will promote the antibiotics research based on natural products to the next level.
新型抗菌分子的发现对于解决当前抗生素危机问题起着关键作用。天然产物一直是药物发现的重要来源。本文综述了 2016 年 1 月至 2020 年期间，从 11 个结构类别中选择的 256 个具有新型化合物或新结构且 MIC 低于 10μg/mL 或 10μM 的天然产物，这些天然产物是通过 SciFinder 筛选得到的。本文综述为药物化学家提供了一些有效的抗菌先导化合物，将促进基于天然产物的抗生素研究进入一个新的水平。
