Beijing AIER Fukang Eye Hospital, China.
Ming Vision Eye Clinic, Beijing, China.
Dis Markers. 2022 May 29;2022:3361172. doi: 10.1155/2022/3361172. eCollection 2022.
The study is aimed at evaluating corneal epithelial thickness changes associated with overnight orthokeratology (ortho-K). In this retrospective study, epithelial thickness was measured using optical coherence tomography (OCT) before and after 1 day, 1 week, 1 month, and 3 months ortho-K nightly lens wear. Compared with pre-orthokeratology measurements, central (2 mm) corneal epithelium thickness was significantly reduced at 1 day, 1 week, 1 month, and 3 months with ortho-K ( < 0.05). Paracentral (2 mm5 mm annular ring) epithelial thickness was also significantly reduced at superior temporal, inferior temporal, temporal, and inferior locations after ortho-K ( < 0.05), while midperipheral (5 mm6 mm annular ring) epithelial thickness was greater post- than pre-ortho-K at superior, superior temporal, inferior temporal, inferior, and inferior nasal locations ( < 0.05). In other zones, superior, superior nasal, nasal, and inferior nasal in paracentral annular ring and temporal and superior nasal in midperipheral ring, epithelial thickness underwent no significant change. Ortho-K lens wear caused the central corneal epitheliums to thin. The temporal half zones become thinner in paracentral zones and thicker in midperipheral zones.
本研究旨在评估过夜角膜塑形术（ortho-K）相关的角膜上皮厚度变化。在这项回顾性研究中，使用光学相干断层扫描（OCT）在佩戴 ortho-K 夜戴镜前和 1 天、1 周、1 个月和 3 个月后测量上皮厚度。与塑形前测量值相比，中央（2mm）角膜上皮厚度在佩戴 ortho-K 1 天、1 周、1 个月和 3 个月时显著变薄（<0.05）。在上颞、下颞、颞和下象限，旁中央（2mm-5mm 环形带）上皮厚度在佩戴 ortho-K 后也显著降低（<0.05），而中周（5mm-6mm 环形带）上皮厚度在佩戴 ortho-K 后在上、上颞、下颞、下和下鼻象限较塑形前增加（<0.05）。在其他区域，旁中央环形带的上、上鼻、鼻和下鼻象限以及中周环的颞和上鼻象限，上皮厚度无明显变化。ortho-K 镜佩戴导致中央角膜上皮变薄。旁中央区的颞半区变薄，中周区变厚。
