Kazi Abdul Momin, Cortese Margaret M, Yu Ying, Lopman Benjamin, Morrow Ardythe L, Fleming Jessica A, McNeal Monica M, Steele A Duncan, Parashar Umesh D, Zaidi Anita K M, Ali Asad
Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan.
Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
J Infect Dis. 2017 Mar 1;215(5):786-789. doi: 10.1093/infdis/jix028.
Histo-blood group antigens (HBGAs) expressed on enterocytes are proposed receptors for rotaviruses and can be measured in saliva. Among 181 Pakistani infants in a G1P[8] rotavirus vaccine trial who were seronegative at baseline, anti-rotavirus immunoglobulin A seroconversion rates after 3 vaccine doses differed significantly by salivary HBGA phenotype, with the lowest rate (19%) among infants who were nonsecretors (ie, who did not express the carbohydrate synthesized by FUT2), an intermediate rate (30%) among secretors with non-blood group O, and the highest rate (51%) among secretors with O blood group. Differences in HBGA expression may be responsible for some of the discrepancy in the level of protection detected for the current rotavirus vaccines in low-income versus high-income settings.
肠上皮细胞上表达的组织血型抗原（HBGA）被认为是轮状病毒的受体，且可在唾液中检测到。在一项G1P[8]轮状病毒疫苗试验中的181名巴基斯坦婴儿中，这些婴儿在基线时血清学呈阴性，3剂疫苗接种后抗轮状病毒免疫球蛋白A血清转化率因唾液HBGA表型不同而有显著差异，非分泌型婴儿（即不表达由FUT2合成的碳水化合物的婴儿）的转化率最低（19%），非O血型分泌型婴儿的转化率为中等水平（30%），O血型分泌型婴儿的转化率最高（51%）。HBGA表达的差异可能是造成低收入与高收入环境中当前轮状病毒疫苗检测到的保护水平存在差异的部分原因。
