生长抑素对猫胃肠道分泌物及消化性溃疡形成的影响。

Effect of somatostatin on gastrointestinal secretions and peptic ulcer production in cats.

作者信息

Konturek S J, Radecki T, Pucher A, Coy D H, Schally A V

出版信息

Scand J Gastroenterol. 1977;12(3):379-83. doi: 10.3109/00365527709180945.

Abstract

In conscious cats with chronic gastric and pancreatic fisulas, the effect of somatostatin (GH-RIH) on gastric and pancreatic secretion and peptic ulcer formation was examined. GH-RIH infused intravenously in graded doses (range: 0.62 to 5.0 microng/kg-hr) inhibited dose-dependently gastric acid response to pentagastrin but failed to affect acid response to histamine. GH-RIH caused a marked inhibition of pepsin secretion induced by both pentagastrin and histamine and decreased pancreatic bicarbonate but not protein response to exogenous secretin or intraduodenal acid. It effectively prevented the formation of duodenal ulcers produced by prolonged administration of both pentagastrin or histamine.

摘要

在患有慢性胃瘘和胰瘘的清醒猫身上，研究了生长抑素（GH-RIH）对胃和胰腺分泌以及消化性溃疡形成的影响。以分级剂量（范围：0.62至5.0微克/千克·小时）静脉输注生长抑素，剂量依赖性地抑制了对五肽胃泌素的胃酸反应，但未能影响对组胺的胃酸反应。生长抑素显著抑制了由五肽胃泌素和组胺诱导的胃蛋白酶分泌，并降低了胰腺碳酸氢盐分泌，但对外源性促胰液素或十二指肠内酸刺激的蛋白质分泌无影响。它有效地预防了因长期给予五肽胃泌素或组胺而导致的十二指肠溃疡的形成。