Istanbul University, Institute of Oncology, Department of Tumour Pathology, Istanbul, Turkey.
Kocaeli University, Faculty of Dentistry, Department of Oral and Maxillofacial Radiology, Kocaeli, Turkey.
J Stomatol Oral Maxillofac Surg. 2021 Jun;122(3):278-282. doi: 10.1016/j.jormas.2020.06.002. Epub 2020 Jun 18.
The aim of this retrospective study was to investigate the characteristics of cemento-osseous dysplasia (COD) lesions for devising a clinical algorithm to help management decisions, specifically discussing the need for a possible surgical intervention versus solely follow-up.
One hundred thirty-five subjects were thus identified having previously diagnosed and treated for COD from the archives of the pathology in between 2005-2015. These were then re-evaluated. Demographic features, radiographic and histopathologic findings were assessed.
The most frequent variant was the focal type (n=83), and the mandible (n=131) was predominantly affected jaw bone. Female predilection was evident for all subtypes. Almost half of the lesions (n=72) presented with mixed radiolucent and radiopaque appearances in radiography at the time of the biopsy. Cementicles/psammoma body-like calcifications and trabecular pattern were the most common hard tissue appearances.
COD lesions are non-neoplastic fibro-osseous lesions which can exhibit similar histopathologic and radiologic features with other bone lesions. Ideally, these lesions should be clinically identified and followed-up. Considering the possible complications, a thorough knowledge of these lesions and their differentials is essential in order to avoid unnecessary surgical interventions.
本回顾性研究旨在探讨骨化性纤维瘤（COD）病变的特征，以制定临床算法来辅助管理决策，特别是讨论是否需要可能的手术干预还是仅进行随访。
因此，从 2005 年至 2015 年的病理档案中确定了 135 名先前诊断和治疗过 COD 的患者，然后对其进行重新评估。评估了人口统计学特征、影像学和组织病理学发现。
最常见的变异型是局灶型（n=83），下颌骨（n=131）是最常受累的颌骨。所有亚型均表现出女性偏好。在活检时的放射学检查中，将近一半的病变（n=72）表现为混合性透亮和不透射线的外观。钙化性水泥细胞/砂粒体样和小梁样是最常见的硬组织表现。
COD 病变是非肿瘤性纤维骨性病变，其组织病理学和影像学特征可与其他骨病变相似。理想情况下，这些病变应通过临床识别并进行随访。考虑到可能的并发症，为了避免不必要的手术干预，彻底了解这些病变及其鉴别诊断至关重要。
