Singla Ankush, Singh Pushpinder, Panditrao Mridul, Panditrao Minnu M
Department of Anesthesia and Intensive Care, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
Department of Radio Diagnosis, Adesh Institute of Medical Sciences and Research, Bathinda, Punjab, India.
Indian J Crit Care Med. 2020 Apr;24(4):276-280. doi: 10.5005/jp-journals-10071-23410.
Recreational drug abuse is a serious health problem that poses detrimental effects on central nervous system. Neuroimaging plays a pivotal role in the detection of these abnormal changes in the brain associated with the drug abuse. This study focuses on the grading of cerebral atrophy in the opioid-addicted patients and their association with the age and duration of opioid abuse.
Grading of cerebral atrophy in opioid-addicted patients and to assess the probable association between chronic opioid abuse and cerebral atrophy in patients admitted to the intensive care unit (ICU) of a tertiary care hospital.
A retrospective study was carried out on 40 patients of opioid abuse who were admitted in the ICU of the hospital over a period of 2 years. Magnetic resonance imaging (MRI) scan of these patients was done using Siemens Avanto 1.5 Tesla scanner.
All the patients were male with 25 patients having varying degrees of cerebral atrophy as assessed from Pasquier scale. Majority of the patients ( = 14) on chronic opioid abuse had global cortical atrophy (GCA) score of 1 indicative of mild cerebral atrophy. The associated factors like the duration of abuse and age of presentation had significant association with the cerebral atrophic changes in the brain ( < 0.05).
Opioid-dependent patients with long-term substance abuse had probable association with the atrophic changes in brain as assessed from neuroimaging. The progressing age and longer duration of drug abuse may foster significant alterations to the brain structure leading to varied degree of cerebral atrophy.
Singla A, Singh P, Panditrao M, Panditrao MM. Is Chronic Opioid Abuse Associated with Cerebral Atrophy? An Observational Study. Indian J Crit Care Med 2020;24(4):276-280.
娱乐性药物滥用是一个严重的健康问题，对中枢神经系统有有害影响。神经影像学在检测与药物滥用相关的大脑异常变化中起着关键作用。本研究聚焦于阿片类药物成瘾患者的脑萎缩分级及其与阿片类药物滥用年龄和时长的关联。
对阿片类药物成瘾患者的脑萎缩进行分级，并评估三级护理医院重症监护病房（ICU）收治患者中慢性阿片类药物滥用与脑萎缩之间可能存在的关联。
对在两年期间入住该医院ICU的40例阿片类药物滥用患者进行回顾性研究。使用西门子Avanto 1.5特斯拉扫描仪对这些患者进行磁共振成像（MRI）扫描。
所有患者均为男性，根据帕斯奎尔量表评估，25例患者有不同程度的脑萎缩。大多数长期滥用阿片类药物的患者（ = 14）的全脑皮质萎缩（GCA）评分为1，表明为轻度脑萎缩。滥用时长和就诊年龄等相关因素与大脑的脑萎缩变化有显著关联（ < 0.05）。
从神经影像学评估来看，长期药物滥用的阿片类药物依赖患者可能与脑萎缩变化有关。年龄增长和药物滥用时间延长可能促使大脑结构发生显著改变，导致不同程度的脑萎缩。
辛格拉A、辛格P、潘迪特劳M、潘迪特劳MM。慢性阿片类药物滥用与脑萎缩有关吗？一项观察性研究。《印度重症监护医学杂志》2020年；24（4）：276 - 280。
