在一所寄宿学校甲型流感暴发期间金刚烷胺的预防性使用。
Prophylactic use of amantadine in a boarding school outbreak of influenza A.
作者信息
Davies J R, Grilli E A, Smith A J, Hoskins T W
出版信息
J R Coll Gen Pract. 1988 Aug;38(313):346-8.
Amantadine was used in a boarding school to control an outbreak of influenza A H3N2. Of 859 pupils 79% took amantadine and almost all of them completed the course (100 mg per day for 15 days). While amantadine was being taken the number of clinical cases of influenza was considerably fewer than that predicted on the basis of previous outbreaks of influenza A at the school. However, during the month following the course of amantadine, the outbreak continued with many clinical cases confirmed by virus isolation. The advantages and limitations of amantadine prophylaxis are discussed.
金刚烷胺被用于一所寄宿学校以控制甲型H3N2流感的暴发。在859名学生中，79%服用了金刚烷胺，且几乎所有人都完成了疗程（每日100毫克，共15天）。在服用金刚烷胺期间，流感临床病例数明显少于基于该校以往甲型流感暴发情况所预测的数量。然而，在金刚烷胺疗程结束后的一个月内，疫情仍在继续，许多临床病例经病毒分离得以确认。文中讨论了金刚烷胺预防的优缺点。
Zotero 插件