Department of Infectious Diseases, Department of Respiratory, Renmin Hospital, School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, China.
Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Cell Infect Microbiol. 2020 May 22;10:284. doi: 10.3389/fcimb.2020.00284. eCollection 2020.
To investigate the early epidemic of COVID-19, a total of 176 confirmed COVID-19 cases in Shiyan city, Hubei province, China were surveyed. Our data indicated that the rate of emergence of early confirmed COVID-19 cases in Hubei province outside Wuhan was dependent on migration population, and the second-generation of patients were family clusters originating from Wuhan travelers. Epidemiological investigation indicated that the reproductive number (R) under containment strategies was 1.81, and asymptomatic SARS-CoV-2 carriers were contagious with a transmission rate of 10.7%. Among the 176 patients, 53 were admitted to the Renmin Hospital of Hubei University of Medicine. The clinical characteristics of these 53 patients were collected and compared based on a positive RT-PCR test and presence of pneumonia. Clinical data showed that 47.2% (25/53) of COVID-19 patients were co-infected with , and COVID-19 patients coinfected with had a higher percentage of monocytes ( < 0.0044) and a lower neutrophils percentage ( < 0.0264). Therefore, it is important to assess the transmissibility of infected asymptomatic individuals for SARS-CoV-2 transmission; moreover, clinicians should be alert to the high incidence of co-infection with in COVID-19 patients.
为了调查 COVID-19 的早期疫情，对中国湖北省十堰市的 176 例确诊 COVID-19 病例进行了调查。我们的数据表明，湖北省武汉以外地区早期确诊 COVID-19 病例的出现率取决于流动人口，第二代患者是来自武汉旅行者的家庭聚集。流行病学调查表明，在控制策略下的繁殖数（R）为 1.81，无症状的 SARS-CoV-2 携带者具有传染性，传播率为 10.7%。在这 176 名患者中，有 53 名被收入湖北医药学院人民医院。根据 RT-PCR 检测阳性和存在肺炎，收集并比较了这 53 名患者的临床特征。临床数据表明，COVID-19 患者中有 47.2%（25/53）合并感染，合并感染 的 COVID-19 患者单核细胞比例更高（<0.0044），中性粒细胞比例更低（<0.0264）。因此，评估受感染无症状个体对 SARS-CoV-2 传播的传染性非常重要；此外，临床医生应警惕 COVID-19 患者合并感染的发生率很高。
