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新型冠状病毒肺炎(COVID-19):起源、传播、可能的治疗方法及全球负担。

COVID-19: Emergence, Spread, Possible Treatments, and Global Burden.

机构信息

Department of Pharmacology, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, India.

Department of Health Sciences, School of Education and Health, Cape Breton University, Sydney, NS, Canada.

出版信息

Front Public Health. 2020 May 28;8:216. doi: 10.3389/fpubh.2020.00216. eCollection 2020.

DOI:10.3389/fpubh.2020.00216
PMID:32574299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7270802/
Abstract

The Coronavirus (CoV) is a large family of viruses known to cause illnesses ranging from the common cold to acute respiratory tract infection. The severity of the infection may be visible as pneumonia, acute respiratory syndrome, and even death. Until the outbreak of SARS, this group of viruses was greatly overlooked. However, since the SARS and MERS outbreaks, these viruses have been studied in greater detail, propelling the vaccine research. On December 31, 2019, mysterious cases of pneumonia were detected in the city of Wuhan in China's Hubei Province. On January 7, 2020, the causative agent was identified as a new coronavirus (2019-nCoV), and the disease was later named as COVID-19 by the WHO. The virus spread extensively in the Wuhan region of China and has gained entry to over 210 countries and territories. Though experts suspected that the virus is transmitted from animals to humans, there are mixed reports on the origin of the virus. There are no treatment options available for the virus as such, limited to the use of anti-HIV drugs and/or other antivirals such as Remdesivir and Galidesivir. For the containment of the virus, it is recommended to quarantine the infected and to follow good hygiene practices. The virus has had a significant socio-economic impact globally. Economically, China is likely to experience a greater setback than other countries from the pandemic due to added trade war pressure, which have been discussed in this paper.

摘要

冠状病毒(CoV)是一大类病毒,已知可引起从普通感冒到急性呼吸道感染等各种疾病。感染的严重程度可能表现为肺炎、急性呼吸窘迫综合征,甚至死亡。直到 SARS 爆发,这组病毒才受到极大的关注。然而,自 SARS 和 MERS 爆发以来,这些病毒得到了更详细的研究,推动了疫苗研究。2019 年 12 月 31 日,中国湖北省武汉市发现了神秘的肺炎病例。2020 年 1 月 7 日,病原体被确定为一种新型冠状病毒(2019-nCoV),后来世界卫生组织将该疾病命名为 COVID-19。该病毒在中国武汉地区广泛传播,并已进入 210 多个国家和地区。尽管专家怀疑该病毒是从动物传播给人类的,但关于该病毒的起源存在各种报道。目前尚无针对该病毒的治疗方法,仅限于使用抗 HIV 药物和/或其他抗病毒药物,如瑞德西韦和加洛韦。为了控制病毒,建议对感染者进行隔离,并遵循良好的卫生习惯。该病毒在全球范围内造成了重大的社会经济影响。从经济角度来看,由于疫情带来的贸易战压力,中国可能比其他国家受到更大的冲击,这在本文中进行了讨论。

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