Independent Scholar.
Department of Molecular, Cellular, and Developmental Biology, and the Life Sciences Institute, University of Michigan , Ann Arbor, MI, USA.
Autophagy. 2020 Dec;16(12):2271-2272. doi: 10.1080/15548627.2020.1782022. Epub 2020 Jun 24.
Given the devastating consequences of the current COVID-19 pandemic and its impact on all of us, the question arises as to whether manipulating the cellular degradation (recycling, waste disposal) mechanism known as macroautophagy/autophagy (in particular, the selective degradation of virus particles, termed virophagy) might be a beneficial approach to fight the novel coronavirus, SARS-CoV-2. Knowing that "autophagy can reprocess everything", it seems almost inevitable that, sooner rather than later, a further hypothesis-driven work will detail the role of virophagy as a fundamental "disposal strategy" against COVID-19, yielding most needed therapeutic interventions. ATG, autophagy-related; CoV/CoVs coronavirus/coronaviruses; COVID-19, coronavirus disease 2019; MERS-CoV, Middle East respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.
鉴于当前 COVID-19 大流行的破坏性后果及其对我们所有人的影响，人们不禁要问，操纵细胞降解（回收、废物处理）机制——即众所周知的巨自噬/自噬（特别是病毒颗粒的选择性降解，称为噬病毒作用）——是否可能成为对抗新型冠状病毒 SARS-CoV-2 的有益方法。鉴于“自噬可以重新处理一切”，自噬作用作为对抗 COVID-19 的基本“处置策略”的作用，似乎迟早会有进一步的假设驱动研究详细阐明，从而产生最需要的治疗干预措施。 ATG，自噬相关；CoV/CoVs 冠状病毒/冠状病毒；COVID-19，冠状病毒病 2019；MERS-CoV，中东呼吸综合征冠状病毒；SARS-CoV-2，严重急性呼吸综合征冠状病毒 2。
