抗击 COVID-19 亮点：自噬在 SARS-CoV-2 感染中发挥作用？
Highlights in the fight against COVID-19: does autophagy play a role in SARS-CoV-2 infection?
机构信息
Department of Biological Sciences, Oakland University , Rochester, MI, USA.
Life Sciences Institute, University of Michigan , Ann Arbor, MI, USA.
出版信息
Autophagy. 2020 Dec;16(12):2123-2127. doi: 10.1080/15548627.2020.1844940. Epub 2020 Nov 5.
In the preceding months, the novel SARS-CoV-2 pandemic has devastated global communities. The need for safe and effective prophylactic and therapeutic treatments to combat COVID-19 - the human disease resulting from SARS-CoV-2 infection - is clear. Here, we present recent developments in the effort to combat COVID-19 and consider whether SARS-CoV-2 may potentially interact with the host autophagy pathway. : ACE2, angiotensin converting enzyme II; βCoV, betacoronavirus; COVID-19, Coronavirus Disease 2019; CQ, chloroquine; DMV, double-membrane vesicle; GI, gastrointestinal; HCQ, hydroxychloroquine; IL, interleukin; MAP1LC3/LC3, microtubule associated protein 1 light chain 3; MEFs, mouse embryonic fibroblasts; MERS-CoV, Middle East respiratory syndrome coronavirus; MHV, murine hepatitis virus; PE, phosphatidylethanolamine; SARS-CoV, severe acute respiratory syndrome coronavirus; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; TMPRSS2, transmembrane serine protease 2; TNF, tumor necrosis factor; WHO, World Health Organization.
在过去的几个月里，新型 SARS-CoV-2 大流行使全球社区遭受重创。显然，需要安全有效的预防和治疗方法来对抗 COVID-19——由 SARS-CoV-2 感染引起的人类疾病。在这里，我们介绍了抗击 COVID-19 的最新进展，并探讨了 SARS-CoV-2 是否可能与宿主自噬途径相互作用。: ACE2，血管紧张素转化酶 II；βCoV，β 冠状病毒；COVID-19，2019 年冠状病毒病；CQ，氯喹；DMV，双层膜囊泡；GI，胃肠道；HCQ，羟氯喹；IL，白细胞介素；MAP1LC3/LC3，微管相关蛋白 1 轻链 3；MEFs，小鼠胚胎成纤维细胞；MERS-CoV，中东呼吸综合征冠状病毒；MHV，鼠肝炎病毒；PE，磷脂酰乙醇胺；SARS-CoV，严重急性呼吸综合征冠状病毒；SARS-CoV-2，严重急性呼吸综合征冠状病毒 2；TMPRSS2，跨膜丝氨酸蛋白酶 2；TNF，肿瘤坏死因子；WHO，世界卫生组织。
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