Université Côte d'Azur, CNRS, INSERM, IRCAN, FHU-OncoAge, Centre Antoine Lacassagne , Nice, France.
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Bethesda, MD, USA.
Autophagy. 2020 Dec;16(12):2276-2281. doi: 10.1080/15548627.2020.1844433. Epub 2020 Nov 29.
In less than eleven months, the world was brought to a halt by the COVID-19 outbreak. With hospitals becoming overwhelmed, one of the highest priorities concerned critical care triage to ration the scarce resources of intensive care units. Which patient should be treated first? Based on what clinical and biological criteria? A global joint effort rapidly led to sequencing the genomes of tens of thousands of COVID-19 patients to determine the patients' genetic signature that causes them to be at risk of suddenly developing severe disease. In this commentary, we would like to consider some points concerning the use of a multifactorial risk score for COVID-19 severity. This score includes macroautophagy (hereafter referred to as autophagy), a critical host process that controls all steps harnessed by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus. ATG5: autophagy related 5; BECN1: beclin 1; COVID-19: coronavirus infectious disease-2019; EGR1: early growth response 1; ER: endoplasmic reticulum; DMVs: double-membrane vesicles; IBV: infectious bronchitis virus; MAP1LC3: microtubule associated protein 1 light chain 3; LC3-I: proteolytically processed, non-lipidated MAP1LC3; LC3-II: lipidated MAP1LC3; MEFs: mouse embryonic fibroblasts; MERS-CoV: Middle East respiratory syndrome-coronavirus; MHV: mouse hepatitis virus; NSP: non-structural protein; PEDV: porcine epidemic diarrhea virus; PLP2-TM: membrane-associated papain-like protease 2; SARS-CoV-2: severe acute respiratory syndrome coronavirus 2; TGEV: transmissible gastroenteritis virus.
在不到十一个月的时间里，COVID-19 疫情使世界陷入停顿。随着医院不堪重负，当务之急之一是对重症监护进行危急护理分类，以合理分配重症监护病房的稀缺资源。应该首先治疗哪位患者？基于哪些临床和生物学标准？全球的共同努力迅速导致对成千上万的 COVID-19 患者的基因组进行测序，以确定导致他们突然患上严重疾病的患者遗传特征。在这篇评论中，我们想考虑一些关于使用 COVID-19 严重程度的多因素风险评分的问题。该评分包括巨自噬（以下简称自噬），这是一种控制严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）病毒利用的所有步骤的关键宿主过程。 ATG5：自噬相关 5；BECN1：beclin 1；COVID-19：冠状病毒传染病 2019；EGR1：早期生长反应 1；ER：内质网；DMVs：双膜囊泡；IBV：传染性支气管炎病毒；MAP1LC3：微管相关蛋白 1 轻链 3；LC3-I：蛋白水解处理的、非脂化的 MAP1LC3；LC3-II：脂化的 MAP1LC3；MEFs：小鼠胚胎成纤维细胞；MERS-CoV：中东呼吸综合征冠状病毒；MHV：鼠肝炎病毒；NSP：非结构蛋白；PEDV：猪流行性腹泻病毒；PLP2-TM：膜相关木瓜蛋白酶样蛋白酶 2；SARS-CoV-2：严重急性呼吸综合征冠状病毒 2；TGEV：传染性胃肠炎病毒。
