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在一家大学医院中,念珠菌血症患者的死亡率相关风险因素。

Risk factors associated with mortality among patients who had candidemia in a university hospital.

机构信息

Universidade Federal de Uberlândia, Faculdade de Medicina, Uberlândia, MG, Brasil.

Universidade Federal de Uberlândia, Instituto de Biologia, Uberlândia, MG, Brasil.

出版信息

Rev Soc Bras Med Trop. 2020 Jun 22;53:e20190206. doi: 10.1590/0037-8682-0206-2019. eCollection 2020.

DOI:10.1590/0037-8682-0206-2019
PMID:32578699
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7310371/
Abstract

INTRODUCTION

Bloodstream infection due to Candida spp. is a primary cause of morbidity and mortality in tertiary hospitals.

METHODS

In this retrospective study, we included patients with a positive blood culture for Candida spp. after 48 h of hospitalization.

RESULTS

A total of 335 patients who had candidemia were included in this study. Risk factors associated with mortality were hospitalization in internal medicine units and surgical clinics, age >60 years, mechanical ventilation, orotracheal intubation, hemodialysis, corticosteroids use, and C. parapsilosis infection.

CONCLUSIONS

This study highlights the importance of health care related to invasive procedures and actions to improve patient immunity.

摘要

简介

血流感染念珠菌属是三级医院发病率和死亡率的主要原因。

方法

在这项回顾性研究中,我们纳入了住院 48 小时后血培养阳性的念珠菌属患者。

结果

本研究共纳入 335 例念珠菌血症患者。与死亡率相关的危险因素包括内科和外科住院、年龄 >60 岁、机械通气、经口气管插管、血液透析、皮质类固醇使用和近平滑念珠菌感染。

结论

本研究强调了与侵入性操作相关的医疗保健以及改善患者免疫力的重要性。

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J Med Microbiol. 2018 Jul;67(7):903-914. doi: 10.1099/jmm.0.000756. Epub 2018 May 30.
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Prevalence, virulence factors and antifungal susceptibility of Candida spp. isolated from bloodstream infections in a tertiary care hospital in Brazil.巴西一家三级保健医院血流感染分离的念珠菌属的流行率、毒力因子和抗真菌药敏性。
Mycoses. 2018 Jan;61(1):11-21. doi: 10.1111/myc.12695. Epub 2017 Sep 22.
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Clinical manifestations of candidemia caused by uncommon Candida species and antifungal susceptibility of the isolates in a regional hospital in Taiwan, 2007-2014.
J Pediatr (Rio J). 2024 May-Jun;100(3):267-276. doi: 10.1016/j.jped.2023.11.005. Epub 2023 Dec 22.
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The Impact of Corticosteroids on the Outcome of Fungal Disease: a Systematic Review and Meta-analysis.皮质类固醇对真菌病结局的影响:一项系统评价和荟萃分析。
Curr Fungal Infect Rep. 2023;17(1):54-70. doi: 10.1007/s12281-023-00456-2. Epub 2023 Feb 23.
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Epidemiology, clinical characteristics, and outcome of candidemia in critically ill patients in Germany: a single-center retrospective 10-year analysis.德国重症患者念珠菌血症的流行病学、临床特征及转归:一项单中心10年回顾性分析
Ann Intensive Care. 2020 Oct 16;10(1):142. doi: 10.1186/s13613-020-00755-8.
2007-2014 年台湾地区一家医院不常见念珠菌引起的念珠菌血症的临床表现和分离株的抗真菌药敏性。
J Microbiol Immunol Infect. 2019 Aug;52(4):612-619. doi: 10.1016/j.jmii.2017.08.007. Epub 2017 Aug 26.
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Eur J Intern Med. 2017 Jun;41:33-38. doi: 10.1016/j.ejim.2017.03.005. Epub 2017 Mar 15.
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Candida glabrata among Candida spp. from environmental health practitioners of a Brazilian Hospital.巴西一家医院环境卫生从业者所分离出的念珠菌属中的光滑念珠菌。
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