Stewart R S, Devous M D, Rush A J, Lane L, Bonte F J
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75235-9070.
Am J Psychiatry. 1988 Apr;145(4):442-9. doi: 10.1176/ajp.145.4.442.
Dynamic single-photon emission computed axial tomography (CAT) with inhaled xenon-133 was used to measure regional cerebral blood flow in 10 drug-free patients with DSM-III-diagnosed panic disorder and in five normal control subjects. All subjects underwent regional cerebral blood flow studies while at rest or during normal saline infusion and during sodium lactate infusion. Six of the 10 patients and none of the control subjects experienced lactate-induced panic attacks. Lactate infusion markedly raised hemispheric blood flow levels in both control subjects and patients who did not panic. Patients who did panic experienced either a minimal increase or a decrease in hemispheric blood flow.
动态单光子发射计算机断层扫描（CAT）结合吸入氙-133，用于测量10名符合《精神疾病诊断与统计手册》第三版（DSM-III）诊断标准的无药物治疗的惊恐障碍患者和5名正常对照者的局部脑血流量。所有受试者在静息状态、输注生理盐水期间以及输注乳酸钠期间均接受了局部脑血流量研究。10名患者中有6名，而对照组中无人出现乳酸诱发的惊恐发作。在未出现惊恐发作的对照组受试者和患者中，输注乳酸显著提高了半球血流量水平。出现惊恐发作的患者半球血流量要么仅有轻微增加，要么减少。
