Reiman E M, Raichle M E, Robins E, Butler F K, Herscovitch P, Fox P, Perlmutter J
Am J Psychiatry. 1986 Apr;143(4):469-77. doi: 10.1176/ajp.143.4.469.
Positron emission tomography was used to study eight patients with panic disorder who were vulnerable to lactate-induced panic, eight patients with panic disorder who were not vulnerable to lactate-induced panic, and 25 normal control subjects. Patients who were vulnerable to lactate-induced panic had several abnormalities in the resting, nonpanic state: an abnormal hemispheric asymmetry of parahippocampal blood flow, blood volume, and oxygen metabolism; abnormally high whole brain metabolism; and abnormal susceptibility to episodic hyperventilation. A hypothetical model for the neurobiology of panic disorder, involving the abnormal parahippocampal region and its afferent and efferent connections, is proposed.
正电子发射断层扫描技术被用于研究8名易受乳酸诱发惊恐发作的惊恐障碍患者、8名不易受乳酸诱发惊恐发作的惊恐障碍患者以及25名正常对照者。易受乳酸诱发惊恐发作的患者在静息、非惊恐状态下存在多种异常：海马旁回血流、血容量和氧代谢的半球不对称异常；全脑代谢异常高；以及对发作性过度通气异常敏感。本文提出了一个关于惊恐障碍神经生物学的假说模型，该模型涉及异常的海马旁回区域及其传入和传出连接。
