Stössel Sandra, Neu Marie A, Wingerter Arthur, Bloch Wilhelm, Zimmer Philipp, Paret Claudia, Malki Khalifa El, Baumann Freerk T, Russo Alexandra, Henninger Nicole, Lehmann Nadine, Otto Henrike, Faber Jörg
Center for Pediatric and Adolescent Medicine, Childhood Cancer Center, University Medical Center Mainz, Mainz, Germany.
Department of Molecular and Cellular Sport Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Cologne, Germany.
Front Pediatr. 2020 Jun 5;8:243. doi: 10.3389/fped.2020.00243. eCollection 2020.
In cancer patients, the impairment in muscle function is a frequently observed phenomenon. However, comprehensive evaluation of the effect of exercise training on muscle function in childhood cancer patients (CCPs) is sparse and therefore investigated in the MUCKI trial. In the randomized controlled MUCKI trial, CCPs during intensive cancer treatment and aged 4-18 years were recruited. Eligible patients were enrolled soon after diagnosis as long as they were physically and mentally able to participate in exercise testing and training. Patients of the exercise group ( = 16) participated in average 2.7 ± 1.2 times per week in a combined resistance and endurance training with moderate exercise intensity, for a time period of 8.0 ± 2.1 weeks, while patients of the control group ( = 17) received usual care. Leg strength was evaluated as the primary endpoint. Secondary endpoints were 6-min walk performance, arm strength, body composition, fatigue, and health-related quality of life. Comparisons of pre- and post-intervention results were evaluated by baseline and stratification criteria adjusted analysis and showed positive effects for the exercise group regarding leg strength [ = 5.733; = 0.027; = 0.223], walking performance [ = 4.270; = 0.049; = 0.146], fatigue [ = 8.353; = 0.013; = 0.391], self-esteem [ = 6.823; = 0.040; = 0.532], and self-reported strength and endurance capacity [ = 6.273; = 0.046; = 0.511]. No significant differences were found for the other parameters. Within one of the first randomized controlled trials, the present study provides evidence for a positive effect of combined training in CCPs during intensive cancer treatment. Further research is needed to confirm these results and to evaluate their clinical impact. NCT02612025.
在癌症患者中，肌肉功能受损是一种常见现象。然而，关于运动训练对儿童癌症患者（CCP）肌肉功能影响的综合评估却很少，因此在MUCKI试验中对此进行了研究。在随机对照的MUCKI试验中，招募了年龄在4至18岁、正在接受强化癌症治疗的CCP。符合条件的患者在确诊后只要身心能够参与运动测试和训练，就会尽快入组。运动组（n = 16）的患者平均每周参加2.7±1.2次中等运动强度的抗阻和耐力联合训练，为期8.0±2.1周，而对照组（n = 17）的患者接受常规护理。腿部力量被评估为主要终点。次要终点包括6分钟步行表现、手臂力量、身体成分、疲劳以及与健康相关的生活质量。通过基线和分层标准调整分析对干预前后的结果进行比较，结果显示运动组在腿部力量[β = 5.733；P = 0.027；Cohen's d = 0.223]、步行表现[β = 4.270；P = 0.049；Cohen's d = 0.146]、疲劳[β = 8.353；P = 0.013；Cohen's d = 0.391]、自尊[β = 6.823；P = 0.040；Cohen's d = 0.532]以及自我报告的力量和耐力能力[β = 6.273；P = 0.046；Cohen's d = 0.511]方面有积极影响。其他参数未发现显著差异。在首批随机对照试验之一中，本研究为强化癌症治疗期间CCP进行联合训练的积极效果提供了证据。需要进一步研究来证实这些结果并评估其临床影响。NCT02612025。
