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淀粉样蛋白β（Aβ）的拓扑分布可预测Aβ阳性轻度认知障碍向痴呆的进展。

Topographical distribution of Aβ predicts progression to dementia in Aβ positive mild cognitive impairment.

作者信息

Pascoal Tharick A, Therriault Joseph, Mathotaarachchi Sulantha, Kang Min Su, Shin Monica, Benedet Andrea L, Chamoun Mira, Tissot Cecile, Lussier Firoza, Mohaddes Sara, Soucy Jean-Paul, Massarweh Gassan, Gauthier Serge, Rosa-Neto Pedro

机构信息

Translational Neuroimaging Laboratory Alzheimer's Disease Research Unit The McGill University Research Centre for Studies in Aging McGill University Montreal Quebec Canada.

Department of Neurology and Neurosurgery McGill University Montreal Quebec Canada.

出版信息

Alzheimers Dement (Amst). 2020 Jun 21;12(1):e12037. doi: 10.1002/dad2.12037. eCollection 2020.

DOI:10.1002/dad2.12037
PMID:32582834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7306519/
Abstract

INTRODUCTION

Abnormal brain amyloid beta (Aβ) is typically assessed in vivo using global concentrations from cerebrospinal fluid and positron emission tomography (PET). However, it is unknown whether the assessment of the topographical distribution of Aβ pathology can provide additional information to identify, among global Aβ positive individuals, those destined for dementia.

METHODS

We studied 260 amnestic mild cognitive impairment (MCI) subjects who were Aβ-PET positive with [F]florbetapir. Using [F]florbetapir, we assessed the percentage of voxels sowing Aβ abnormality as well as the standardized uptake value ratio (SUVR) values across brain regions. Regressions tested the predictive effect of Aβ on progression to dementia over 2 years.

RESULTS

Neither global nor regional [F]florbetapir SUVR concentrations predicted progression to dementia. In contrast, the spatial extent of Aβ pathology in regions comprising the default mode network was highly associated with the development of dementia over 2 years.

DISCUSSION

These results highlight that the regional distribution of Aβ abnormality may provide important complementary information at an individual level regarding the likelihood of Aβ positive MCI to progress to dementia.

摘要

引言

异常的脑淀粉样β蛋白（Aβ）通常在体内通过脑脊液和正电子发射断层扫描（PET）的整体浓度进行评估。然而，尚不清楚对Aβ病理的地形分布进行评估是否能提供额外信息，以在整体Aβ阳性个体中识别出那些注定会发展为痴呆症的个体。

方法

我们研究了260名遗忘型轻度认知障碍（MCI）受试者，他们使用[F] florbetapir进行Aβ-PET检查呈阳性。使用[F] florbetapir，我们评估了显示Aβ异常的体素百分比以及全脑各区域的标准化摄取值比率（SUVR）。回归分析测试了Aβ对2年内发展为痴呆症的预测作用。

结果

无论是整体还是区域的[F] florbetapir SUVR浓度都不能预测发展为痴呆症。相比之下，包括默认模式网络在内的区域中Aβ病理的空间范围与2年内痴呆症的发展高度相关。

讨论

这些结果突出表明，Aβ异常的区域分布可能在个体层面上提供重要的补充信息，以了解Aβ阳性MCI发展为痴呆症的可能性。

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