在人视网膜母细胞瘤细胞中检测神经节苷脂作为N-羟乙酰神经氨酸特异性肿瘤相关的汉努齐乌-戴歇尔抗原。
Detection of gangliosides as N-glycolylneuraminic acid-specific tumor-associated Hanganutziu-Deicher antigen in human retinoblastoma cells.
作者信息
Higashi H, Sasabe T, Fukui Y, Maru M, Kato S
机构信息
Department of Pathology, Osaka University.
出版信息
Jpn J Cancer Res. 1988 Aug;79(8):952-6. doi: 10.1111/j.1349-7006.1988.tb00060.x.
Abstract
Gangliosides were shown to bear the tumor-associated N-glycolylneuraminic acid (NeuGc)-specific Hanganutziu-Deicher (HD) antigen expressed in human retinoblastoma cells. HD antigenic gangliosides were detected by thin-layer chromatography/enzyme-immunostaining using affinity-purified chicken antibody against GM3 containing NeuGc and horseradish peroxidase-conjugated anti-chicken IgG. One to four species of the antigenic gangliosides were detected from all of 4 cell lines, Y79, WERI-Rb1, TOTL1, and YK, as well as freshly cultured retinoblastoma cells and isolated tumor tissue. All cases contained GM3(NeuGc) as an HD antigen. No HD antigenic ganglioside was detected in normal retinal tissues by the same procedure.
摘要
神经节苷脂被证明带有肿瘤相关的N-羟乙酰神经氨酸（NeuGc）特异性的汉加努齐乌-戴歇尔（HD）抗原，该抗原在人视网膜母细胞瘤细胞中表达。使用针对含NeuGc的GM3的亲和纯化鸡抗体和辣根过氧化物酶偶联的抗鸡IgG，通过薄层色谱/酶免疫染色检测HD抗原性神经节苷脂。从所有4种细胞系Y79、WERI-Rb1、TOTL1和YK以及新鲜培养的视网膜母细胞瘤细胞和分离的肿瘤组织中均检测到1至4种抗原性神经节苷脂。所有病例均含有GM3（NeuGc）作为HD抗原。通过相同程序在正常视网膜组织中未检测到HD抗原性神经节苷脂。
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