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1
Detection of gangliosides as N-glycolylneuraminic acid-specific tumor-associated Hanganutziu-Deicher antigen in human retinoblastoma cells.在人视网膜母细胞瘤细胞中检测神经节苷脂作为N-羟乙酰神经氨酸特异性肿瘤相关的汉努齐乌-戴歇尔抗原。
Jpn J Cancer Res. 1988 Aug;79(8):952-6. doi: 10.1111/j.1349-7006.1988.tb00060.x.
2
Specific expression of unusual GM2 ganglioside with Hanganutziu-Deicher antigen activity on human colon cancers.具有汉根纽齐乌-戴歇尔抗原活性的异常GM2神经节苷脂在人类结肠癌上的特异性表达。
Jpn J Cancer Res. 1987 Mar;78(3):251-60.
3
Characterization of N-glycolylneuraminic acid-containing gangliosides as tumor-associated Hanganutziu-Deicher antigen in human colon cancer.含N-羟乙酰神经氨酸神经节苷脂作为人结肠癌中肿瘤相关的汉努齐乌-戴歇尔抗原的特性分析
Cancer Res. 1985 Aug;45(8):3796-802.
4
Heterophile Hanganutziu-Deicher antigen in ganglioside fractions of human melanoma tissues.人黑色素瘤组织神经节苷脂组分中的嗜异性汉氏-戴氏抗原
Int Arch Allergy Appl Immunol. 1988;85(3):381-3. doi: 10.1159/000234536.
5
Analysis of the expression of Hanganutziu-Deicher (HD) antigen in human malignant melanoma.人类恶性黑色素瘤中汉努齐乌-戴歇尔（HD）抗原表达的分析。
J Dermatol. 1992 Nov;19(11):827-30. doi: 10.1111/j.1346-8138.1992.tb03791.x.
6
Use of biotinylated antibody for the assay of Hanganutziu-Deicher antibodies and antigens in fluids and tissues from cancer patients.使用生物素化抗体检测癌症患者体液和组织中的汉加纽齐乌-戴歇尔抗体和抗原。
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7
Occurrence of tumor-associated ganglioside antigens with Hanganutziu-Deicher antigenic activity on human melanomas.人类黑色素瘤上具有汉努齐乌-戴歇尔抗原活性的肿瘤相关神经节苷脂抗原的出现情况。
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8
Production of monoclonal antibodies directed to Hanganutziu-Deicher active gangliosides, N-glycolylneuraminic acid-containing gangliosides.针对汉加纽齐乌-戴歇尔活性神经节苷脂（含N-羟乙酰神经氨酸的神经节苷脂）的单克隆抗体的制备。
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9
Sensitive enzyme-immunostaining and densitometric determination on thin-layer chromatography of N-glycolylneuraminic acid-containing glycosphingolipids, Hanganutziu-Deicher antigens.含N-羟乙酰神经氨酸的糖鞘脂（汉努齐乌-戴歇尔抗原）的薄层色谱上的敏感酶免疫染色及光密度测定。
J Biochem. 1984 May;95(5):1517-20. doi: 10.1093/oxfordjournals.jbchem.a134760.
10
Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
Am J Ophthalmol. 1983 Sep;96(3):321-5. doi: 10.1016/s0002-9394(14)77822-5.

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1
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7
Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense.获得性癌症情报（CIA）：肿瘤糖基化和唾液酸化编码破解抗肿瘤防御。
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Racotumomab: an anti-idiotype vaccine related to N-glycolyl-containing gangliosides - preclinical and clinical data.Racotumomab：一种与含有 N-乙醯神经醯胺的神经节醣脂有关的抗独特型疫苗——临床前和临床数据。
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10
Immunohistochemical Reactivity of the 14F7 Monoclonal Antibody Raised against N-Glycolyl GM3 Ganglioside in Some Benign and Malignant Skin Neoplasms.抗N-糖基化神经节苷脂GM3产生的14F7单克隆抗体在某些良性和恶性皮肤肿瘤中的免疫组化反应性
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本文引用的文献

1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
THE GANGLIOSIDES.神经节苷脂
J Lipid Res. 1964 Apr;5:145-55.
3
Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.唾液酸的定量测定。II. 比色间苯二酚 - 盐酸法。
Biochim Biophys Acta. 1957 Jun;24(3):604-11. doi: 10.1016/0006-3002(57)90254-8.
4
Hanganutziu-Deicher type-heterophile antigen-positive cells in human cancer tissues demonstrated by membrane immunofluorescence.
Biken J. 1982 Mar;25(1):47-50.
5
Tumor-associated expression of glycosphingolipid Hanganutziu-Deicher antigen in human cancers.人类癌症中糖鞘脂类汉根纽茨尤-戴歇尔抗原的肿瘤相关表达。
Gan. 1984 Nov;75(11):1025-9.
6
Sensitive enzyme-immunostaining and densitometric determination on thin-layer chromatography of N-glycolylneuraminic acid-containing glycosphingolipids, Hanganutziu-Deicher antigens.含N-羟乙酰神经氨酸的糖鞘脂（汉努齐乌-戴歇尔抗原）的薄层色谱上的敏感酶免疫染色及光密度测定。
J Biochem. 1984 May;95(5):1517-20. doi: 10.1093/oxfordjournals.jbchem.a134760.
7
Hanganutziu-Deicher heterophile antigen in human retinoblastoma cells.
Am J Ophthalmol. 1983 Sep;96(3):321-5. doi: 10.1016/s0002-9394(14)77822-5.
8
Characterization of N-glycolyneuraminic acid-containing glycosphingolipids from a Marek's disease lymphoma-derived chicken cell line, MSB1, as tumor-associated heterophile Hanganutziu-Deicher antigens.对源自马立克氏病淋巴瘤的鸡细胞系MSB1中含N-羟乙酰神经氨酸的糖鞘脂进行表征，作为肿瘤相关嗜异性汉-迪抗原。
J Biochem. 1984 Mar;95(3):785-94. doi: 10.1093/oxfordjournals.jbchem.a134670.
9
Specificities of human heterophilic Hanganutziu and Deicher (H-D) antibodies and avian antisera against H-D antigen-active glycosphingolipids.人类嗜异性汉加努齐乌和戴歇尔（H-D）抗体以及禽类抗血清针对具有H-D抗原活性的糖鞘脂的特异性。
Mol Immunol. 1982 Jan;19(1):87-94. doi: 10.1016/0161-5890(82)90250-4.
10
Detection of antibodies to gangliosides in pathologic human sera. Serum-sickness type heterophile antibodies.病理性人血清中神经节苷脂抗体的检测。血清病型嗜异性抗体。
Adv Exp Med Biol. 1980;125:359-67. doi: 10.1007/978-1-4684-7844-0_34.

在人视网膜母细胞瘤细胞中检测神经节苷脂作为N-羟乙酰神经氨酸特异性肿瘤相关的汉努齐乌-戴歇尔抗原。

Detection of gangliosides as N-glycolylneuraminic acid-specific tumor-associated Hanganutziu-Deicher antigen in human retinoblastoma cells.

作者信息

Higashi H, Sasabe T, Fukui Y, Maru M, Kato S

机构信息

Department of Pathology, Osaka University.

出版信息

Jpn J Cancer Res. 1988 Aug;79(8):952-6. doi: 10.1111/j.1349-7006.1988.tb00060.x.

DOI:10.1111/j.1349-7006.1988.tb00060.x
PMID:2460424
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917607/
Abstract

Gangliosides were shown to bear the tumor-associated N-glycolylneuraminic acid (NeuGc)-specific Hanganutziu-Deicher (HD) antigen expressed in human retinoblastoma cells. HD antigenic gangliosides were detected by thin-layer chromatography/enzyme-immunostaining using affinity-purified chicken antibody against GM3 containing NeuGc and horseradish peroxidase-conjugated anti-chicken IgG. One to four species of the antigenic gangliosides were detected from all of 4 cell lines, Y79, WERI-Rb1, TOTL1, and YK, as well as freshly cultured retinoblastoma cells and isolated tumor tissue. All cases contained GM3(NeuGc) as an HD antigen. No HD antigenic ganglioside was detected in normal retinal tissues by the same procedure.

摘要

神经节苷脂被证明带有肿瘤相关的N-羟乙酰神经氨酸（NeuGc）特异性的汉加努齐乌-戴歇尔（HD）抗原，该抗原在人视网膜母细胞瘤细胞中表达。使用针对含NeuGc的GM3的亲和纯化鸡抗体和辣根过氧化物酶偶联的抗鸡IgG，通过薄层色谱/酶免疫染色检测HD抗原性神经节苷脂。从所有4种细胞系Y79、WERI-Rb1、TOTL1和YK以及新鲜培养的视网膜母细胞瘤细胞和分离的肿瘤组织中均检测到1至4种抗原性神经节苷脂。所有病例均含有GM3（NeuGc）作为HD抗原。通过相同程序在正常视网膜组织中未检测到HD抗原性神经节苷脂。