Jang Eun-Sik, Park Jun-Woo, Kweon Haeyong, Lee Kwang-Gill, Kang Seok-Woo, Baek Dong-Heon, Choi Je-Yong, Kim Seong-Gon
Department of Oral and Maxillofacial Surgery, Hallym University, Kyoungkido, Korea.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Jun;109(6):831-6. doi: 10.1016/j.tripleo.2009.10.038. Epub 2010 Feb 16.
The objective of this study was to determine the capability of silk fibroin powder as a biomaterial template for the restoration of peri-implant defects when mixed with Choukroun platelet-rich fibrin (PRF) in vivo.
Ten New Zealand white rabbits were used for this study. Using a trephine bur (diameter 7.0 mm), 2 monocortical defects were prepared. Subsequently, 2 dental implants were installed into the tibia (diameter 3.0 mm, length 10.0 mm). In the experimental group, the peri-implant defect was filled with a combination graft of silk fibroin powder and Choukroun PRF. The control was left in an unfilled state. The animals were killed at 8 weeks. Subsequently, a removal torque test and a histomorphometric analysis were done.
The removal torque for the experimental group was 30.34 +/- 5.06 N.cm, whereas it was 21.86 +/- 3.39 N.cm for the control. The difference between the 2 groups was statistically significant (P = .010). Mean new bone formation was 51.93 +/- 27.90% in the experimental group and 11.67 +/- 15.12% in the control (P = .003). Mean bone-to-implant contact was 43.07 +/- 21.96% in the experimental group and 15.37 +/- 23.84% in the control (P = .002).
A peri-implant defect can be successfully repaired by the application of Choukroun PRF and silk fibroin powder.
本研究的目的是确定丝素蛋白粉末与舒可复富血小板纤维蛋白（PRF）混合后作为生物材料模板在体内修复种植体周围缺损的能力。
本研究使用了10只新西兰白兔。使用环钻（直径7.0毫米）制备2个单皮质缺损。随后，将2颗牙种植体植入胫骨（直径3.0毫米，长度10.0毫米）。在实验组中，种植体周围缺损用丝素蛋白粉末和舒可复PRF的联合移植物填充。对照组保持未填充状态。动物在8周时处死。随后，进行了去除扭矩测试和组织形态计量分析。
实验组的去除扭矩为30.34±5.06牛·厘米，而对照组为21.86±3.39牛·厘米。两组之间的差异具有统计学意义（P = 0.010）。实验组的平均新骨形成率为51.93±27.90%，对照组为11.67±15.12%（P = 0.003）。实验组的平均骨与种植体接触率为43.07±21.96%，对照组为15.37±23.84%（P = 0.002）。
应用舒可复PRF和丝素蛋白粉末可成功修复种植体周围缺损。
