富血小板纤维蛋白修复种植体周围缺损。
Restoration of a peri-implant defect by platelet-rich fibrin.
机构信息
Resident, Department of Oral and Maxillofacial Surgery, Gangneung-Wonju National University, Gangneung, Republic of Korea.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol. 2012 Apr;113(4):459-63. doi: 10.1016/j.tripleo.2011.03.043. Epub 2011 Jul 20.
OBJECTIVE
The objective of this study was to evaluate the application of platelet-rich fibrin (PRF) into a peri-implant defect in vivo.
STUDY DESIGN
Eight New Zealand white rabbits were used for this study. Two peri-implants with defects sized 3.0 × 5.0 mm (width × length) were prepared after drilling to host the dental implant in the tibia. Subsequently, the 2 dental implants were installed (diameter, 3.0 mm and length, 8.0 mm). In the experimental group, PRF was applied into the bony defect. In the control group, the peri-implant defect was left unfilled. The animals were humanely killed 8 weeks after implantation and histomorphometric analysis was done.
RESULTS
In the histomorphometric analysis, mean new bone formation was 29.30% ± 7.50% in the experimental group and 11.06% ± 8.94% in the control group (P = .020). Mean bone-to-implant contact was 39.43% ± 7.39% in the experimental group and 17.11% ± 8.12% in the control group (P = .006).
CONCLUSIONS
In the animal model, peri-implant defect sized 3.0 × 5.0 mm (width × length) was successfully repaired by the application of PRF alone.
目的
本研究旨在评估富血小板纤维蛋白（PRF）在种植体周围缺损中的应用。
研究设计
本研究使用了 8 只新西兰白兔。在胫骨中钻孔以植入牙种植体后，制备了两个大小为 3.0×5.0mm（宽×长）的种植体周围缺损。随后，安装了 2 个牙种植体（直径 3.0mm，长度 8.0mm）。实验组将 PRF 应用于骨缺损中，对照组则不填充种植体周围缺损。植入 8 周后，通过组织形态计量学分析对动物进行人道处死。
结果
在组织形态计量学分析中，实验组的新骨形成率为 29.30%±7.50%，对照组为 11.06%±8.94%（P=0.020）。实验组的骨-种植体接触率为 39.43%±7.39%，对照组为 17.11%±8.12%（P=0.006）。
结论
在动物模型中，单独应用 PRF 可成功修复 3.0×5.0mm（宽×长）的种植体周围缺损。
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