Moreno-Ajona David, McHugh James Alexander, Hoffmann Jan
Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
NIHR-Wellcome Trust King's Clinical Research Facility/SLaM Biomedical Research Centre, King's College Hospital, London, United Kingdom.
Front Neurol. 2020 Jun 10;11:453. doi: 10.3389/fneur.2020.00453. eCollection 2020.
Neuroimaging plays an essential role in the diagnostic workup of idiopathic intracranial hypertension with the aims to exclude secondary causes of elevated intracranial pressure and to identify imaging signs that are commonly observed in this disorder. As a valuable expansion of brain imaging, the imaging of the retina using optical coherence tomography has been of increasing value. In particular, this is the case with the latest devices that allow a more accurate distinction between a reduction in retinal nerve fiber layer thickness due to an improvement of papilledema or due to a worsening caused by optic nerve atrophy. Although optical coherence tomography does not yet replace the other elements of the diagnostic workup, it is likely to play an increasing role in diagnosis and follow-up of idiopathic intracranial hypertension. The review focuses on the main findings in neuroimaging, including structural and vascular alterations as well as on the relevance of optical coherence tomography.
神经影像学在特发性颅内高压的诊断检查中起着至关重要的作用,其目的是排除颅内压升高的继发性原因,并识别该疾病中常见的影像学征象。作为脑成像的一项有价值的扩展,利用光学相干断层扫描对视网膜进行成像的价值日益凸显。特别是,最新的设备能够更准确地区分因视乳头水肿改善导致的视网膜神经纤维层厚度减少,以及因视神经萎缩导致的厚度恶化。虽然光学相干断层扫描尚未取代诊断检查的其他要素,但它很可能在特发性颅内高压的诊断和随访中发挥越来越重要的作用。这篇综述聚焦于神经影像学的主要发现,包括结构和血管改变,以及光学相干断层扫描的相关性。