Li Fan, Shang Qingli, Tang Guangxian, Zhang Hengli, Yan Xiaowei, Ma Lihua, Geng Yulei, Zhang Qing
Department of Ophthalmology, Shijiazhuang No. 1 Hospital, Shijiazhuang, Hebei 050000, China.
Department of Ophthalmology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China.
J Ophthalmol. 2020 Jun 7;2020:9634543. doi: 10.1155/2020/9634543. eCollection 2020.
To compare differences in peripapillary and macular choroidal thickness in pseudoexfoliative glaucoma (PXG) eyes, nonexfoliative fellow eyes, and normal eyes.
This case-control study included 37 PXG patients (group A: 37 PXG eyes; group B: 37 nonexfoliative fellow eyes) and 37 sex-, age-, and axial length-matched healthy volunteer eyes (group C). Peripapillary and macular choroidal thickness and volume were measured in all subjects via enhanced-depth imaging-optical coherence tomography.
The average peripapillary (AP) choroidal thickness was (130.10 ± 46.14) m, (131.43 ± 46.00) m, and (147.89 ± 53.32) m; average macular (AM) choroidal thickness was (191.72 ± 68.07) m, (204.62 ± 69.54) m, and (215.10 ± 45.40) m; and average volume was (0.59 ± 0.21) m, (0.63 ± 0.21) m, and (0.65 ± 0.14) m in groups A, B, and C, respectively. NIP choroidal thickness was significantly lower in groups A and B than in group C ( < 0.05). TIM and TOM choroidal thickness and volume were significantly lower in group A than in group C ( < 0.05). NIM, SIM, NOM, IOM, AM choroidal thickness and volume, and CSM choroidal thickness were significantly lower in group A than in group B ( < 0.05). CSM, TIM, and TOM in group A and TIM, TOM choroidal thickness, and volume in group B were significantly lower than in group C ( < 0.05).
NIP choroidal thickness in PXG eyes and nonexfoliative fellow eyes and temporal macular choroidal thickness in PXG eyes were significantly lower than in normal eyes. Macular choroidal thickness (except in temporal regions) was significantly lower in PXG eyes than in nonexfoliative fellow eyes. Changes in peripapillary and macula choroidal thickness further elucidate the choroid's role in PXG development and progression.
比较假性剥脱性青光眼（PXG）患眼、未患眼及正常眼的视乳头周围和黄斑区脉络膜厚度差异。
本病例对照研究纳入37例PXG患者（A组：37只PXG患眼；B组：37只未患眼）和37名性别、年龄及眼轴长度匹配的健康志愿者眼（C组）。通过增强深度成像光学相干断层扫描测量所有受试者的视乳头周围和黄斑区脉络膜厚度及体积。
A组、B组和C组的平均视乳头周围（AP）脉络膜厚度分别为（130.10±46.14）μm、（131.43±46.00）μm和（147.89±53.32）μm；平均黄斑（AM）脉络膜厚度分别为（191.72±68.07）μm、（204.62±69.54）μm和（215.10±45.40）μm；平均体积分别为（0.59±0.21）mm³、（0.63±0.21）mm³和（0.65±0.14）mm³。A组和B组的视乳头鼻侧（NIP）脉络膜厚度显著低于C组（P<0.05）。A组的视乳头颞侧（TIM）和视乳头颞下（TOM）脉络膜厚度及体积显著低于C组（P<0.05）。A组的视乳头鼻下（NIM）、视乳头颞上（SIM）、视乳头颞下（NOM）、视乳头颞下（IOM）、黄斑（AM）脉络膜厚度及体积，以及视乳头黄斑中心凹下（CSM）脉络膜厚度均显著低于B组（P<0.05）。A组的CSM、TIM和TOM，以及B组的TIM、TOM脉络膜厚度及体积均显著低于C组（P<0.05）。
PXG患眼和未患眼的视乳头鼻侧脉络膜厚度以及PXG患眼的颞侧黄斑脉络膜厚度均显著低于正常眼。PXG患眼的黄斑脉络膜厚度（颞侧区域除外）显著低于未患眼。视乳头周围和黄斑区脉络膜厚度的变化进一步阐明了脉络膜在PXG发生和发展中的作用。
