Pradita-Ukrit Suntornwit, Vattanavanit Veerapong
Critical Care Medicine Unit, Division of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla 90110, Thailand.
Crit Care Res Pract. 2020 Jun 8;2020:2981079. doi: 10.1155/2020/2981079. eCollection 2020.
Thiamine administration has been shown to improve survival in a postcardiac arrest animal study. We aimed to evaluate the efficacy of thiamine in comatose out-of-hospital cardiac arrest (OHCA) patients following return of spontaneous circulation.
A randomized, double-blinded, placebo-controlled study was conducted. Thirty-seven OHCA patients were randomly assigned to receive either thiamine 100 mg every 8 hours or a placebo. The primary outcome was 28-day all-cause mortality.
Over the course of 2 years, 37 patients were randomized to either receive thiamine ( = 20) or a placebo ( = 17). The primary outcome was not different between the groups: 10/20 (50%) in the thiamine group vs. 8/17 (47.1%) in the placebo group (=0.93 by the log-rank test). There were no significant differences in secondary outcomes between the groups (good neurological outcome, lactate level, and S100B level).
In this study, there were no significant differences in survival outcome. Further studies with a larger population are necessary to confirm these results.
在一项心脏骤停后动物研究中，已证明给予硫胺素可提高生存率。我们旨在评估硫胺素对院外心脏骤停（OHCA）昏迷患者自主循环恢复后的疗效。
进行了一项随机、双盲、安慰剂对照研究。37例OHCA患者被随机分配，每8小时接受100mg硫胺素或安慰剂治疗。主要结局是28天全因死亡率。
在2年的研究过程中，37例患者被随机分配接受硫胺素治疗（n = 20）或安慰剂治疗（n = 17）。两组的主要结局无差异：硫胺素组为10/20（50%），安慰剂组为8/17（47.1%）（对数秩检验P = 0.93）。两组的次要结局（良好神经功能结局、乳酸水平和S100B水平）无显著差异。
在本研究中，生存结局无显著差异。需要进行更大规模人群的进一步研究来证实这些结果。
