Walker-Batson D, Wendt J S, Devous M D, Barton M M, Bonte F J
Department of Communication Sciences, Texas Woman's University, Denton 76204.
Brain Lang. 1988 Mar;33(2):311-22. doi: 10.1016/0093-934x(88)90071-5.
A 65-year-old man with well-defined crossed aphasia secondary to right cerebral infarction 10 years previously was studied for current language and cognitive abilities and regional cerebral blood flow (rCBF) during cognitive activation measured by single-photon emission tomography (SPECT). Reversed hemispheric lateralization was demonstrated by qualitative aspects of the patient's constructional deficits, dominant parietal lobe signs, and absence of the neglect syndrome. Language activation procedures during SPECT produced focal increases in rCBF to both frontal lobes with a phoneme detection task and to right temporal and parietal lobes with a math task. The authors stress the complexities of assessing brain/language mechanisms in vivo and demonstrate variabilities in rCBF during language activation dependent on task selection.
一名65岁男性，10年前因右侧脑梗死继发明确的交叉性失语，现对其当前的语言和认知能力以及认知激活期间的局部脑血流量（rCBF）进行研究，采用单光子发射断层扫描（SPECT）进行测量。患者的结构性缺陷、优势顶叶体征以及无忽视综合征等定性特征表明存在半球侧化反转。SPECT期间的语言激活程序在音素检测任务中使双侧额叶的rCBF局灶性增加，在数学任务中使右侧颞叶和顶叶的rCBF增加。作者强调了在体内评估脑/语言机制的复杂性，并证明了语言激活期间rCBF的变异性取决于任务选择。
