Roberts F L, Dixon J, Lewis G T, Tackley R M, Prys-Roberts C
Sir Humphry Davy Department of Anaesthesia, University of Bristol, Bristol Royal Infirmary.
Anaesthesia. 1988 Mar;43 Suppl:14-7. doi: 10.1111/j.1365-2044.1988.tb09061.x.
A simple, manually controlled infusion scheme for continuous administration of propofol was derived by simulation of a computer algorithm designed to achieve a predetermined blood concentration of propofol within 2 minutes and to maintain a constant blood level for the duration of surgery. The manual infusion scheme for a target blood propofol concentration of 3 micrograms/ml, consisted of a loading dose of 1 mg/kg followed immediately by an infusion of 10 mg/kg/hour for 10 minutes, 8 mg/kg/hour for the next 10 minutes and 6 mg/kg/hour thereafter. An overall mean blood propofol concentration of 3.67 micrograms/ml was achieved within 2 minutes and maintained stable for the subsequent 80-90 minutes of surgery. The decrease of systolic and diastolic arterial pressures at induction was much less than that previously described after larger induction doses of propofol and there was a negligible haemodynamic response to laryngoscopy and intubation or to the subsequent surgery. The quality of induction and maintenance of anaesthesia was satisfactory in every patient.
通过模拟一种计算机算法得出了一种简单的、手动控制的丙泊酚持续输注方案，该算法旨在在2分钟内达到预定的丙泊酚血药浓度，并在手术期间维持恒定的血药水平。目标血丙泊酚浓度为3微克/毫升的手动输注方案包括：负荷剂量1毫克/千克，随后立即以10毫克/千克/小时的速度输注10分钟，接下来的10分钟以8毫克/千克/小时的速度输注，之后以6毫克/千克/小时的速度输注。在2分钟内达到了总体平均血丙泊酚浓度3.67微克/毫升，并在随后的80 - 90分钟手术中保持稳定。诱导时收缩压和舒张压的下降远小于先前报道的较大诱导剂量丙泊酚后的下降幅度，并且喉镜检查和插管或随后的手术引起的血流动力学反应可忽略不计。每位患者的麻醉诱导和维持质量均令人满意。
