Sear J W, Shaw I, Wolf A, Kay N H
Nuffield Department of Anaesthetics, John Radcliffe Hospital, Headington, Oxford.
Anaesthesia. 1988 Mar;43 Suppl:18-22. doi: 10.1111/j.1365-2044.1988.tb09062.x.
The peri-operative and postoperative effects of propofol given by infusion were compared with halothane as a supplement to nitrous oxide-oxygen anaesthesia for body surface surgery in patients who breathed spontaneously. Anaesthesia was induced after opioid premedication, with either propofol 2.5 mg/kg or thiopentone 4-5 mg/kg which were followed respectively by an infusion of propofol 12 mg/kg/hour for 10 minutes and at a variable rate thereafter, or by halothane at a mean inspired concentration of 1.2%. Maintenance of anaesthesia required a median rate of infusion of propofol of 149.4 micrograms/kg/minute. The cardiovascular effects during induction and maintenance of anaesthesia were similar in the two groups. The overall incidence of side effects was low but immediate recovery was significantly faster in patients who received propofol.
在自主呼吸的患者进行体表手术时，将丙泊酚输注给药的围手术期和术后效果与氟烷作为氧化亚氮 - 氧气麻醉的补充剂进行了比较。在给予阿片类药物进行术前用药后诱导麻醉，使用2.5mg/kg丙泊酚或4 - 5mg/kg硫喷妥钠，随后分别以12mg/kg/小时的速度输注丙泊酚10分钟，之后以可变速度输注，或以平均吸入浓度1.2%的氟烷进行诱导。维持麻醉所需的丙泊酚输注中位数速率为149.4微克/千克/分钟。两组在麻醉诱导和维持期间的心血管效应相似。副作用的总体发生率较低，但接受丙泊酚的患者立即恢复明显更快。
